Apramycin

Dose and dosage

Cattle

a) For bacterial enteritis caused by susceptible organisms: 20–40 mg/kg PO daily in drinking water
b) Calves: For the treatment of colibacillosis or salmonellosis: 1–2 sachets to be administered in the drinking water, milk, or milk replacer to provide 20–40 mg of apramycin activity per kg of bodyweight daily according to the severity of the disease. Continue treatment for 5 days.

Swine

For bacterial enteritis caused by susceptible organisms:
a) Treated pigs should consume enough water to receive 12.5 mg/kg body weight per day for 7 days. Add to drinking water at a rate of 375 mg per gallon. After adding to water, stir and allow to stand for 15 minutes, then stir again. 
b) 20–40 mg/kg PO daily in drinking water
c) Pigs: To be administered via the drinking water. Add 1 small measure (4.4 mL) or 1 sachet of soluble powder per 20 L of drinking water.

Poultry

a) For bacterial enteritis caused by susceptible organisms: To be administered via drinking water to provide 250–500 mg of apramycin activity per liter for 5 days. This may be achieved by adding 50 g apramycin per 100–200 liters of water.


Applications: salmonellosis, Respiratory tract infection, Colibacillosis, Bacterial Enteritis

Apramycin is an aminoglycoside that is bactericidal against many gramnegative bacteria (E. coli, Pseudomonas, Salmonella, Klebsiella, Proteus, Pasturella, Treponema hyodysenteriae, Bordetella bronchiseptica), Staphylococcus and Mycoplasma. It prevents protein synthesis by susceptible bacteria, presumably by binding to the 30S ribosomal subunit.

Should substantial amounts of the drug be absorbed, both ototoxicity and
nephrotoxicity are a distinct possibility