Ciprofloxacin

For susceptible infections:
a) Ciprofloxacin: 5–15 mg/kg PO q12h Avoid or reduce dosage of these drugs in animals with severe renal failure; avoid in young animals or in pregnant or breeding animals. (Vaden & Papich 1995)

15-20 mg/kg body weight q12 hours

For susceptible infections:
a) 5–15 mg/kg PO q12h; Avoid or reduce dosage of these drugs in animals with severe renal failure; avoid in young animals or in pregnant or breeding animals. (Vaden & Papich 1995)
b) For UTI: 10 mg/kg PO once daily (q24h) for 7–14 days For skin, soft tissue infections: 10–15 mg/kg PO once daily (q24h) for 7–14 days. For bone systemic infections, bacteremia and more resistant pathogens (e.g., Enterobacter): 20 mg/kg PO once daily (q24h) for 7–14 days (Greene et al. 2006)
c) For pyoderma: 11 mg/kg PO q12h (Miller 2005)

Tablet: Adult: Respiratory Tract Infections: 500 to 750 mg twice daily (7 to 14 days) Urinary tract infections: 250 to 750 mg twice daily (3 to 10 days) Pelvic Inflammatory Diseases: 500 to 750 mg twice daily (14 days) Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera): 500 mg twice daily (1 to 5 days) Typhoid fever: 500 mg twice daily (7 days) Intra-abdominal infections: 500 to 750 mg twice daily (5 to 14 days) Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks) Skin and Soft Tissue Infections: 500 to 750 mg twice daily (7 to 14 days) Bone and Joint Infections: 500 to 750 mg twice daily (max. 3 months) Gonorrhea: 500 mg as a single dose Neutropenic patients with fever due to bacterial infection: 500 to 750 mg twice daily co-administered with appropriate antibacterials. Meningitis: 500 mg as a single dose. Surgical prophylaxis: 500 mg as a single dose, 60 minutes before the procedure. Suspension: Pediatric: 10-20 mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy depends on the type and severity of the infection.Extended-release tablet: In uncomplicated urinary tract infection (acute cystitis), the recommended dose of extended-release tablet is 1000 mg tablet once daily for three days.For IV infusion: Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days. Administration: Instruction for the use of Ciprofloxacin IV infusion- Check the bag for minute leaks by squeezing the inner bag firmly. If leaks are found, or if seal is not intact, discard the solution. Do not use if the solution is cloudy or a precipitate is present. Do not use flexible bags in series connections. Close flow control clamp of administration set. Remove cover from port at bottom of bag. Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated. Suspend bag from hanger. Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Ciprofloxacin IV infusion. Open flow control clamp to expel air from set.Close clamp. Regulate rate of administration with flow control clamp Duration of treatment: The duration of treatment depends upon the severity of infection, clinical response and bacteriological findings. For acute infections the usual treatment period is 5 to 10 days. Generally treatment should be continued for 3 days after the signs and symptoms of the infection have been disappeared.

For susceptible infections:
a) 5–15 mg/kg PO twice daily (Williams 2000)

5–20 mg/kg PO q12h (Ivey & Morrisey 2000)

For susceptible gram-negative infections:
a) Using ciprofloxacin 500 mg tablets: 20–40 mg/kg PO twice daily. Crushed tablet goes into suspension well, but must be shaken well before administering. (McDonald 1989)
b) Ciprofloxacin (using crushed tablets): 20 mg/kg PO q12h (Bauck & Hoefer 1993)
c) Ciprofloxacin (using crushed tablets or suspend) 10–15 mg/kg PO q12h (Hoeffer 1995)
d) Ratites: 3–6 mg/kg PO twice daily (Jenson 1998)