Generic medicine

Ciprofloxacin

Ciprofloxacin is indicated for the treatment of Respiratory Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever, Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections ... Read moreCiprofloxacin is indicated for the treatment of Respiratory Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever, Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections, Gonorrhea, Neutropenic patients with fever due to bacterial infection, Meningitis, Surgical prophylaxis.

Brands

150

Class

Antibiotics

Categories

4

Dose and dosage

Cat

For susceptible infections:
a) Ciprofloxacin: 5–15 mg/kg PO q12h Avoid or reduce dosage of these drugs in animals with severe renal failure; avoid in young animals or in pregnant or breeding animals. (Vaden & Papich 1995)

Cattle

15-20 mg/kg body weight q12 hours

Dog

For susceptible infections:
a) 5–15 mg/kg PO q12h; Avoid or reduce dosage of these drugs in animals with severe renal failure; avoid in young animals or in pregnant or breeding animals. (Vaden & Papich 1995)
b) For UTI: 10 mg/kg PO once daily (q24h) for 7–14 days For skin, soft tissue infections: 10–15 mg/kg PO once daily (q24h) for 7–14 days. For bone systemic infections, bacteremia and more resistant pathogens (e.g., Enterobacter): 20 mg/kg PO once daily (q24h) for 7–14 days (Greene et al. 2006)
c) For pyoderma: 11 mg/kg PO q12h (Miller 2005)

Ferrets

For susceptible infections:
a) 5–15 mg/kg PO twice daily (Williams 2000)

Rabbit

5–20 mg/kg PO q12h (Ivey & Morrisey 2000)

Birds (Other)

For susceptible gram-negative infections:
a) Using ciprofloxacin 500 mg tablets: 20–40 mg/kg PO twice daily. Crushed tablet goes into suspension well, but must be shaken well before administering. (McDonald 1989)
b) Ciprofloxacin (using crushed tablets): 20 mg/kg PO q12h (Bauck & Hoefer 1993)
c) Ciprofloxacin (using crushed tablets or suspend) 10–15 mg/kg PO q12h (Hoeffer 1995)
d) Ratites: 3–6 mg/kg PO twice daily (Jenson 1998)

Clinical notes

Applications:
  • Urinary tract infection
Indication Notes:
Ciprofloxacin is indicated for the treatment of Respiratory Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever, Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections ... Read moreCiprofloxacin is indicated for the treatment of Respiratory Tract Infections,Urinary tract infections, Pelvic Inflammatory Diseases, Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera), Typhoid fever, Intra-abdominal infections, Prostatitis, Skin and Soft Tissue Infections, Bone and Joint Infections, Gonorrhea, Neutropenic patients with fever due to bacterial infection, Meningitis, Surgical prophylaxis.
Avoid In:

N/A

Contraindication Notes:
It is contraindicated in patients who have known hypersensitivity to Ciprofloxacin or other quinolones.
Ciprofloxacin is a synthetic fluoroquinolone. It has bactericidal activity against a wide range of gram-positive and gram-negative organisms. It inhibits bacterial DNA synthesis by binding with the bacterial enzyme-DNA gyrase and topoisomerase IV which are responsible for DNA supercoiling.
Concurrent administration of Ciprofloxacin should be avoided with Magnesium or Aluminum containing antacids or sucralfate or with other products containing Calcium, Iron or Zinc. These products may be taken two hours after or six hours before Ciprofloxacin. Ciprofloxacin should not be taken concurrently with milk or other dairy products, since absorption of Ciprofloxacin may be significantly reduced. Dietary calcium is a part of a meal, however, does not significantly affect the absorption of Ciprofloxacin.
Side effects include- nausea and other gastrointestinal disturbances, headache, dizziness, joint pain and skin rashes.
Overdose following Ciprofloxacin administration may lead to seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria, haematuria, & reversible renal toxicity.
There are no adequate and well-controlled studies in pregnant women. Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus and mother. Ciprofloxacin is excreted in human milk. Due to the potential risk of articular damage, Ciprofloxacin should not be used during lactation.
Patients receiving Ciprofloxacin should be instructed to drink fluids liberally. It should be used with caution in patients with suspected or known CNS disorders such as epilepsy or other factors which predispose to seizures and convulsion. Avoid in patients with known QT prolongation, hypokalemia.
Although effective in clinical trials, Ciprofloxacin is not a drug of first choice in pediatric population.

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