Danofloxacin Mesylate

Applications: Bovine Respiratory Disease (BRD), Acute Mastitis, Enteritis, E.Coli Infection
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Danofloxacin mesylate injection is indicated for the treatment of Bovine Respiratory Disease (BRD) associated with Mannheimia (Pasturella) hemolytica and P. multocida in cattle (not dairy or veal). Because of the drug’s spectrum of activity, it may also be of benefit in the treatment of infections caused by Histophilus somni (Haemophilus somnus) or M. bovis, but the drug is not labeled (at the time of writing) for treating these pathogens.

Danofloxacin is a fluoroquinolone bactericidal antibiotic that inhibits bacterial DNA-gyrase, preventing DNA supercoiling and DNA synthesis. Fluoroquinolones have good activity against many gram-negative bacilli and some gram-positive cocci (Staphylococcus aureus and Staphylococcus intermedius). In general, fluoroquinolones have a dose or concentration dependant effect rather than a time-dependant bactericidal effect.

Hypersensitivity reactions and lameness have been reported after administration to calves at labeled dosages. Incidence rates are not known, but they are believed to occur uncommonly. In cattle, subcutaneous injections can cause a local tissue reaction that may result in trim loss.

High dosages, 18–60 mg/kg for 3–6 days in feeder calves reportedly can cause arthropathies/lameness (consistent with other fluoroquinolones), CNS stimulation (ataxia, nystagmus, tremors), inappetence, recumbency, depression, and exophthalmos. Some (3/6) 21-dayold calves receiving 18 mg/kg twice 48 hours apart developed nasal pad erythema. 

Studies performed in adult dogs given 2.4 mg/kg/day PO for 90 days developed no observable effects.

Meat: 5 Days

Milk: 2 days