Diminazene Aceturate Generic Medicine | VetSafeCare.Com

Generic medicine

Diminazene Aceturate

Active against Babesia spp., Hepatozoon canis, Trypanosoma spp., Theileria spp.

Brands

0

Categories

2

Browse brands Open class

Dose and dosage

Cat

For treatment of cytauxzoonosis:
a) 3–5 mg/kg IM one time, tick control remains the best means of preventing disease as treatment attempts meet with little success. (Blagburn 2005)
b) 2 mg/kg IM, repeat in one week. (Greene et al. 2006)

Horse

For treatment of susceptible protozoal (Trypanosomes, Babesia) infections (West Africa):
a) In general, 3.5 mg/kg IM one time. Depending on susceptibility, dose can be increased to 8 mg/kg. Do not exceed 4 grams total dose per animal. (Label directions; Berenil®—Intervet West Africa)

Cattle

For treatment of susceptible protozoal (Trypanosomes, Babesia) infections (West Africa):
a) In general, 3.5 mg/kg IM one time. Depending on susceptibility, dose can be increased to 8 mg/kg. Do not exceed 4 grams total dose per animal. (Label directions; Berenil®—Intervet West Africa)

Dog

For treatment of Babesia:
a) 3.5–5 mg/kg IM, once for B. canis, repeat in 24 hours for B. gibsoni. Risk for neurotoxicity higher when total dosages are 7 mg/kg or higher. (Toboada & Lobetti 2006)
b) For small Babesia (Okinawa): 3.5 mg/kg IM; repeat once in 24 hours. (Brosey 2003)
c) For treatment of Babesia (South Africa): 4.2 mg/kg IM. Do not repeat within a 21-day period. (Miller et al. 2005) For treatment of African trypanosomiasis:
a) 3.6–7 mg/kg IM every 2 weeks as needed to control relapse or reinfection. (Barr 2006)

Sheep and Goat

For treatment of susceptible protozoal (Trypanosomes, Babesia) infections (West Africa):
a) In general, 3.5 mg/kg IM one time. Depending on susceptibility, dose can be increased to 8 mg/kg. Do not exceed 4 grams total dose per animal. (Label directions; Berenil®—Intervet West Africa)

Clinical notes

Applications:
  • Babesiosis
  • Theileriosis
Indication Notes:

Active against Babesia spp., Hepatozoon canis, Trypanosoma spp., Theileria spp.

Avoid In:

N/A

Contraindication Notes:

Because of adverse events in cats and lack of demonstration of clinical success, it is not recommended for cats.

Diminazene is one of the aromatic diamines that is used for antiprotozoal treatment. Others in this group include imidocarb dipropionate, diminazene aceturate, pentamidine isethionate, and phenamidine isethionate. These drugs inhibit DNA synthesis in protozoa. Clinical use is limited in the United States because it is not commercially available. However, it has been tried for some rare infections in dogs, cats, and horses.

vomiting and diarrhea, pain and swelling at the injection site, and transient decreases in blood pressure. Very rarely (<0.1%) ataxia, seizures, or death have been reported.

severe gastrointestinal, respiratory, nervous system, or musculoskeletal effects.

Meat: 21days

Milk: 3 days.