Erythromycin Stearate + Neomycin Sulfate + Sulphadimidine + Trimethoprim + Bromhexine Hydrochloride
Antibiotic
View Brand Names (1)Dose and dosage
Please follow the trade dose.
Contraindicated in poultry hypersensitive to Erythromycin, Neomycin, Sulphadimidine, Trimethoprim & Bromhexine.
Erythromycin is a macrolide antibiotic, which works by binding to the 50S ribosomal subunit of bacteria & Neomycin is an aminoglycoside antibiotic, which irreversibly binds to the 30S ribosomal subunit of bacteria and thereby inhibits bacterial protein synthesis. Sulphadimidine inhibits nucleic acid synthesis by blocking the conversion of Para aminobenzoic Acid (PABA) to co-enzyme dihydrofolic acid & Trymethoprim inhibits the biosynthesis of tetrahydrofolic acid from dihydrofolic acid and thereby inhibits bacterial nucleic acid synthesis. Bromhexine breakdown the structure of Mucopolysaccharide fiber in mucoid sputum & produces less viscous mucus, facilitates the removal of mucus by ciliary action.
With medicine- This combination reduces the absorption of oral penicillin & Vitamin K. This combination should not be used with Chloramphenicol, Lincomycin, Clindamycin & azole antifungal drugs. With food & others- Not Known.
Common- Diarrhea, anorexia, vomiting, crystal urea, anemia, thrombocytopenia & leukopenia. Rare- Allergic reactions, ototoxicity, nephrotoxicity & intestinal malabsorption.
Well tolerable with recommended dosage regimen. But, acute overdose can result GI distress, CNS toxicity, bone marrow depression & swelling of face.
Use carefully in poultry with impaired liver and kidney functions. Do not use in rabbits, guinea pigs & hamsters. Chronic use of oral aminoglycosides may result in bacterial or fungal superinfections.
Meat- Meat must not be consumed up to 5 days after administration of this medicine.
Egg- Egg must not be consumed up to 6 days after administration of this medicine.