Erythromycin thiocyanate + Sulphadiazine + Trimethoprim

Applications: Pullorum, Necrotic Enteritis, Urogenital Tract Diseases, Fowl Typhoid, Fowl Cholera, Colibacillosis, Septicemia, Enteritis, Mycoplasmosis (CRD), Bronchopneumonia, Coccidiosis, Diarrhea, scours
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When other antibiotics and chemotherapeutics fail due to resistance problem. Calves & foals: indicated in respiratory & gastro-intestinal tract infections like bronchopneumonia, bronchitis, diarrhea, enteritis & scour. 

Fish: gram-positive cocci infections of fish. 

 contraindicated in animals with hypersensitivity to the erythromycin, Sulphadiazine & Trimethoprim. 

This combination provides broad spectrum activity against a wide range of bacterial & some protozoal infections. Erythromycin is a macrolide antibiotic highly effective against gram positive bacteria, and Mycoplasma. It is also effective against some gram-negative bacteria such as Nessaria spp. & Haemophilus spp. Erythromycin works by binding with 50s ribosomal subunit, consequently inhibit protein synthesis of bacteria. Sulphadiazine inhibits biosynthesis of PABA to dihydrosulphonic acid & Trymethoprim inhibits the biosynthesis of tetrahydrofolic acid from dihydrofolic acid. 

 With medicine: Should not be used concurrently with macrolide antibiotic, chloramphenicol, Tylosin & Lincosomide. 

With food & others: In the case of erythromycin, there are no specific foods that should exclude from diet when receiving this medication. 

 Common side effects: No side effects observed at recommended doses. Rare side effects: No side effects observed at recommended doses. 

 This drug is relatively non-toxic. 

 May be used in pregnant & lactating animals but risk & benefit may be considered. 

 Oral erythromycin should not be used in ruminants as diarrhea may occur. 

 Egg 6 days, Meat: 5 days.