Ivermectin + Clorsulon
Anti-parasitic
View Brand Names (5)Dose and dosage
For susceptible parasites:
a) 300 micrograms/kg (0.3 mg/kg) SC in the neck immediately behind the ear
b) For general control of endo- and ectoparasites in potbellied pigs: 300 micro-grams/kg SC or IM once for internal parasites and repeated in 10–14 days for external parasites (only partially effective against whipworms.
a) Rabbits: For Sarcoptes scabiei, Notoedres cati: 0.3–0.4 mg/kg SC, repeat in 14 days.
For ear mites (Psoroptes) 0.2–0.44 mg/kg PO, SC repeat in 8–18 days
b) Rabbits: For treatment of ear mites: 200 micrograms/kg SC and repeated in two weeks. All rabbits in colony should be treated and cages cleaned and disinfected.
c) Rodents and lagomorphs: For treatment of sarcoptoid and some fur mites: 200–250 micrograms/kg SC. Cages should be thoroughly cleaned and disinfected.
d) Mice, Rats, Gerbils, Guinea pigs, Chinchillas: 200 micrograms/kg SC or PO every 7 days for 3 weeks Hamsters: 200–500 micrograms/kg SC or PO every 14 days for 3 weeks
e) Guinea pigs for Trixacarus caviae mites: 500 micrograms/kg SC, repeated at 14 and 28 days.
• Heartworm preventative: 6 mcg/kg every 30 days PO.
• Prior to adulticide treatment: Administer preventative dose for 2 months, and up to 3 months prior to adulticide treatment.
• Heartworm treatment: Ivermectin administered at preventive doses combined with doxycycline at 10 mg/kg PO per day for 28 days.
• Ectoparasite therapy: 200–400 mcg/kg (0.2–0.4 mg/kg) IM, SQ, or PO.
• Demodicosis therapy: Start with 100 mcg/kg/day (0.1 mg/kg) and increase dose by 100 mcg/kg/day to 600 mcg/kg/day (0.6 mg/kg) for 60–120 days PO.
(Successful treatment is confirmed with negative skin scrapings.)
• Sarcoptic mange and cheyletiellosis therapy: 200–400 mcg/kg every 7 days PO or every 14 SQ for 4–6 weeks.
• Ectoparasite therapy: 200–400 mcg/kg (0.2–0.4 mg/kg) IM, SQ, or PO, every 7 days or as needed based on skin scraping and clinical examination.
• Endoparasite therapy: 200–400 mcg/kg (0.2–0.4 mg/kg) weekly SQ or PO.
• Topical: 0.5 mL per ear (0.1 mg/mL) for treating ear mites.
• Injection solution: 200 mcg (0.2 mg)/kg as a single dose SQ.
• Pour-on: 0.5 mg/kg or 1 mL/10 kg (22 lb) of 5 mg/mL solution.
• 200 mcg/kg (0.2 mg/kg) IM, oral paste, or oral solution. Oral solution dose is 1 mL per 50 kg (110 lb). Administer once or as needed as part of a comprehensive worming program.
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Gastrointestinal Roundworms (adults and fourth-stage larvae):
Ostertagia ostertagi (including inhibited O. ostertagi)
O. lyrata
Haemonchus placei
Trichostrongylus axei
T. colubriformis
Cooperia oncophora
C. punctata
C. pectinata
Bunostomum phlebotomum
Nematodirus helvetianus (adults only)
N. spathiger (adults only)
Oesophagostomum radiatum
Lungworms (adults and fourth-stage larvae):
Dictyocaulus viviparus
Liver Flukes:
Fasciola hepatica (adults only)
Cattle Grubs (parasitic stages):
Hypoderma bovis
H. lineatum
Sucking Lice:
Linognathus vituli
Haematopinus eurysternus
Solenopotes capillatus
Mange Mites (cattle scab1):
Psoroptes ovis (syn. P. communis var. bovis)
Sarcoptes scabiei var. bovis
Horses: not be used in foals less than 4 months old
Dog: not recommended for use in puppies less than 6 weeks old.
Ivermectin enhances the release of gamma amino butyric acid (GABA) at presynaptic neurons. GABA acts as an inhibitory neurotransmitter and blocks the post-synaptic stimulation of the adjacent neuron in nematodes or the muscle fiber in arthropods. By stimulating the release of GABA, ivermectin causes paralysis of the parasite and eventual death.
Toxicity may occur at high doses and in breeds in which ivermectin crosses the
blood–brain barrier.
Sensitive breeds include collies, Australian shepherds, Old
English sheepdogs, longhaired whippets, and Shetland sheepdogs.
Toxicity is neurotoxic and signs include hypersalivation, depression, ataxia, difficulty with
vision, coma, and death.
Toxicity may occur at high doses and in breeds in which ivermectin crosses the
blood–brain barrier.
Toxicity is neurotoxic and signs include hypersalivation, depression, ataxia, difficulty with
vision, coma, and death.