Ivermectin + Triclabendazole

control of adult and immature (including inhibited stages) ivermectin-sensitive gastrointestinal nematodes such as Ostertagia sp., Haemonchus sp., Trichostrongylus sp., Cooperia sp., Oesophagostomum sp., Nematodirus sp., Strongyloides sp., Chabertia sp., Trichuris sp., lung worms (Dictyocaulus sp.) in cattle and sheep. As well as sucking lice in cattle (Linognathus sp., Haematopinus sp., Solenopotes sp.), Itch mite (Psorergates sp.) and nasal bots (all larval stages of Oestrus sp.) in sheep and strains of above parasites resistant to other classes of parasiticides. also indicated for adult, immature and early immature triclabendazole-sensitive liver flukes (Fasciola sp.) in cattle and sheep. 

Ivermectin is an antiparasitic drug of the avermectin class. It is a prototype for this class of antiparasitic agents, which also includes eprinomectin and milbemycins (milbemycin and moxidectin). These drugs are macrocyclic lactones and share many similarities, including mechanism of action. These drugs are neurotoxic to parasites by potentiating glutamate-gated chloride ion channels in parasites. Paralysis and death of the parasite are caused by increased permeability to chloride ions and hyperpolarization of nerve cells. These drugs also potentiate other chloride channels, including ones gated by GABA. Mammals ordinarily are not affected because they lack glutamate-gated chloride channels, and there is a lower affinity for other mammalian chloride channels. Because these drugs ordinarily do not penetrate the blood–brain barrier, GABA-gated channels in the CNS of mammals are not affected. Ivermectin is active against intestinal parasites, mites, bots, heartworm microfilaria, and developing larvae. Ivermectin can also produce heartworm adulticide effects when administered long term. Ivermectin has no effect on trematode or cestode parasites.

Triclabendazole bind to b-tubulin, a structural protein, and block polymerization of tubulin into microtubules. This damages the integrity & transport functions of cells within the parasite and ultimately kills the parasite.