Norfloxacin

It has been used anecdotally to treat a variety of infections, including respiratory, urinary tract, skin, and soft tissue infections.

Norfloxacin is one of the oldest fluoroquinolone antibacterial drugs that is used rarely in human or veterinary medicine. Norfloxacin acts via inhibition of DNA gyrase in
bacteria to inhibit DNA and RNA synthesis. It is a bactericidal with a broad spectrum of activity but not as active as other newer fluoroquinolones. Susceptible bacteria
include Staphylococcus spp., E. coli, Proteus spp., Klebsiella spp., and Pasteurella spp. P. aeruginosa is moderately sensitive.

No drug interactions are reported for animals, but the use of norfloxacin
has been uncommon. However, like other quinolones, coadministration
with divalent and trivalent cations, such as products containing aluminum
(e.g., sucralfate), iron, and calcium, may decrease absorption. Do not mix in
solutions or in vials with aluminum, calcium, iron, or zinc because chelation
may occur.