Oxytetracycline

Antibiotic

View Brand Names (28)

Dose and dosage

Cattle

11 mg/kg q12h

Long acting formulations: 20mg/kg IM as a single dose.
Cat

7.5–10 mg/kg q12h IV or 20 mg/kg q12h PO.
Dog

7.5–10 mg/kg q12h IV or 20 mg/kg q12h PO.
Horse

10 mg/kg q24h IM or IV
Swine

6.6–11 mg/kg, up to 10–20 mg/kg, q24h IM or 20 mg/kg q48h IM.

Applications: Anthrax, Babesiosis , Black Quarter (Duplicate), Diarrhea, Dysentery , Hemorrhagic Septicemia, Mastitis, Pneumonia, Brucellosis, Calf Scour, Infectious enteritis, Navel ill, Pyometra, Metritis, Peritonitis, Kiptospirosis, Infectious pleuropneumonia, Calf Diphtheria, Castration, Paratyphoid, foot-rot, salmonellosis, Actinomycosis, anaplasmosis, Colibacillosis, Necrotic Enteritis, Fowl Cholera, Infectious coryza, Streptococcosis, Staphylococcosis
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Prevention of secondary bacterial infection caused by FMD, Ephemeral fever, PPR etc.
Avoid In: Hypersensitivity

Oxytetracycline is one of the oldest tetracycline antibiotics used in animals.
The mechanism of action of tetracyclines is to bind to 30S ribosomal subunit and inhibit protein synthesis. Oxytetracycline is usually bacteriostatic. It has a broad spectrum of activity, including gram-positive and gram-negative bacteria, some protozoa, Rickettsia spp., and Ehrlichia spp. The spectrum also includes Chlamydia spp., spirochetes, Mycoplasma spp., L-form bacteria, and some protozoa (Plasmodium spp. and Entamoeba spp.). Resistance is common among gram-negative bacteria of the Enterobacteriaceae (e.g., Escherichia coli) and Staphylococcus spp.

Tetracyclines have produced kidney injury, but this has been rare with recommended doses. Tetracyclines can affect bone and teeth formation in young animals, but this is usually not a problem with short-term administration. Tetracyclines have caused drug fever in cats, but the mechanism is unknown. Oxytetracycline administration to horses has been associated with colic and diarrhea because of changes in the intestinal bacterial flora.
Azotemia can be seen with high doses, which is attributed to inhibition of protein synthesis in mammalian cells. At very high doses, oxytetracycline can injure other organs (e.g., liver) or cause metabolic acidosis, hemoglobinemia, or myoglobinemia, and the kidneys are injured as a consequence.
Avoid injection volumes for IM greater than 10 mL per site in cattle and greater than 5 mL in pigs because of injection-site lesions

Meat: 7-8 days

Milk: 2 days.

For long acting: Meat 14 days milk 7days.