Pefloxacin

• salmonellosis
• Colibacillosis
• Infectious coryza
• Mycoplasmosis (CRD)
• Pasteurellosis

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Pefloxacin is a fluoroquinolone antibiotic. Flouroquinolones such as pefloxacin possess excellent activity against gram-negative aerobic bacteria such as E.coli and Neisseria gonorrhoea as well as gram-positive bacteria including S. pneumoniae and Staphylococcus aureus. They also posses effective activity against shigella, salmonella, campylobacter, gonococcal organisms, and multi drug resistant pseudomonas and enterobacter.

The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

Acarbose : The therapeutic efficacy of Acarbose can be increased when used in combination with Pefloxacin.
Aceclofenac : Aceclofenac may increase the neuroexcitatory activities of Pefloxacin.
Acemetacin : Acemetacin may increase the neuroexcitatory activities of Pefloxacin.
Acenocoumarol : The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Pefloxacin.
Acetaminophen : The metabolism of Acetaminophen can be decreased when combined with Pefloxacin.

 Meat : Meat must not be consumed up to 7 days after administration of this medicine