Prednisolone + Dexamethasone

Applications: Arthritis, Ketosis, parturient paresis, Indigestion, grass tetany, acute laminitis, tenosynovitis, Dermatitis, Eczema, bronchitis, hepatic dystrophy, skin diseases

Prednisolone is one of the most widely used glucocorticoids. Prednisolone is the active form of prednisone. Prednisolone, like other glucocorticoids, produces
anti-inflammatory and immunosuppressive effects. Anti-inflammatory effects are complex, but via binding to cellular glucocorticoid receptors, prednisolone acts to inhibit inflammatory cells and suppresses expression of inflammatory mediators. Prednisolone is approximately four times more potent than cortisol but only one seventh as potent as dexamethasone. Prednisolone is available as the base (usually as a tablet) or as an injectable acetate form, which can be administered intramuscularly or intraarticularly.

Dexamethasone is a corticosteroid with anti-inflammatory and immunosuppressive effects that are approximately 30 times more potent than cortisol and 6–7 times more potent than prednisolone. Anti-inflammatory effects are complex but primarily occur via inhibition of inflammatory cells and suppression of expression of inflammatory mediators. The difference among formulations is that dexamethasone sodium phosphate is a water-soluble formulation that can be injected intravenously. Dexamethasone solution is in a polyethylene glycol vehicle that should not be administered rapidly intravenously.

May impair growth of young animals

Should not be used with other NSAID drugs

0 days