Sulfadimidine

Antibiotic

View Brand Names (6)

Dose and dosage

Cattle

225 mg/kg, PO, once, followed by 110 mg/kg, PO, q 24 h for 4 doses

Calf: 247 mg/kg, PO, once, followed by 123.75 mg/kg, PO, q 24 h for 3 days as drench or drinking water
Horse

225 mg/kg, PO, once, followed by 110 mg/kg, PO, q 24 h for 4 doses
Swine

247 mg/kg, PO, once, followed by 123.75 mg/kg, PO, q 24 h for 3 days as drench or drinking water
Poultry

Chicken (Excluding layers): 134–195 mg/kg, PO as medicated water, q 24 h for up to 6 day 

Applications: Pneumonia, bronchitis, Hemorrhagic Septicemia, Actinobacillosis, infection of urogenital system, Metritis, Retention of placenta, Abscess, Gastrointestinal infection, Diarrhea, Dysentery , Enteritis, salmonellosis, Septicemia
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Prevention of secondary bacterial infection

Avoid In: Hypersensitivity

Sulfadimidine is a short-acting sulfonamide. It interferes with the synthesis of nucleic acids in sensitive organisms by blocking the conversion of p-aminobenzoic acid (PABA) to the co-enzyme dihydrofolic acid.

Nausea, vomiting, anorexia, diarrhoea, hypersensitivity reactions, SLE, serum sickness-like syndrome, liver necrosis and hepatomegaly, myocarditis, pulmonary eosinophilia and fibrosing alveolitis, vasculitis, hypoglycaemia, hypothyroidism, neurological reactions, jaundice and kernicterus in premature neonates

Sulfadimidine has been assigned to pregnancy category C by the FDA. Sulfonamides cross the placenta. Animal studies with high oral doses of some sulfonamides have revealed an increased incidence of cleft palate and other bony abnormalities.

Because sulfonamides compete with bilirubin for binding to serum albumin, free bilirubin levels rise in the presence of sulfonamides. Neonates are, therefore, at risk for hyperbilirubinemia, jaundice, and kernicterus when sulfonamides are administered to the mother near term

Meat: 7 days

Milk: 3 days