Toltrazuril
Anticoccidial
View Brand Names (1)Dose and dosage
a) For coccidiosis (Cystoisosporosis): 10–20 mg/kg PO one time to all puppies at 3–4 weeks of age will help prevent problems associated with intestinal coccidiosis (Daugschies et al. 2000)
b) For coccidiosis: 15 mg/kg PO once daily for 3–6 days (Dubey, J. & Greene 2006)
c) For Isospora spp. infections: 10–30 mg/kg PO once daily for 1–3 days (Dubey, J.P. et al. 2009)
d) For coccidiosis: 20 mg/kg PO once daily for 3 days. (Marks 2007)
a) For enteroepithelial cycle of toxoplasmosis (oocyst shedding): 5–10 mg/kg PO once daily for 2 days (Dubey, J. & Lappin 2006)
b) For coccidiosis: 30 mg/kg PO once daily for 2–3 days (Greene et al. 2006)
c) For coccidiosis: 20 mg/kg PO once daily for 3 days. (Marks 2007)
a) For ovine coccidiosis (Eimeria ovinoidalis): Controlled study
comparing efficacy against diclazuril: 20 mg/kg PO once. (Mundt et al.
2009)
a) For coccidiosis in raptors: 7 mg/kg PO once daily for 2–3 days (Jones
2004)
a) For coccidiosis in raptors: 7 mg/kg PO once daily for 2–3 days (Jones
2004)
a) For parasitism in Bearded Dragons: 5–15 mg/kg PO once daily for 3
days (Kramer 2006)
Toltrazuril is highly effective against all coccidial intracellular stages (shizogony & gametogony) of all important Eimeria species. Anticoc Vet (Toltrazuril) causes the following cidal changes in the organelles of the parasite at multiple levels.
Cytoplasma vacuolization and enlarged endoplasmic reticulum.
Swollen mitochondria.
Interference with nuclear division.
Damage (bursting) of type II wall-forming bodies in macrogamets.
With medicine: Toltrazuril is compatible with antibiotics such as enrofloxacin, ampicillin, tetracycline, tiamulin and tylosin. With food & others: Not known.
Toltrazuril appears to be well tolerated in birds. An adverse effect profile in
mammals is not well described. Potentially, GI signs could occur. Some horses
receiving the related drug ponazuril, developed blisters on their nose and
mouth, and some, a rash or hives during field trials.
Very limited information is available. Doses of up to 10X in horses were
tolerated without significant adverse effects. 5X overdoses in poultry have
been tolerated without clinical signs noted. Decreased water intake has been
seen if overdoses are greater than 5X.
Poultry: Meat- 8 days, Egg- Should not be used in laying birds producing eggs for human consumption.
Ruminants & Pigs: Meat- 77 days, Milk- Should not be used in lactating animals producing milk for human consumption.