Tranexamic Acid

Antihemorrhagics

View Brand Names (2)

Dose and dosage

Cattle

5-25mg/kg body weight.
Horse

5-25mg/kg body weight.
Dog

10-15mg/kg body weight.
Cat

10-15mg/kg body weight.
Swine

10-15mg/kg body weight.

Applications:
  • Surgical Bleeding
  • Accidental Bleeding
  • Nasal Bleeding
  • Rectal Bleeding
  • Uterine Bleeding
  • Bleeding during or before parturition
  • Hematuria
  • Bleeding due different disease conditions
Indication Notes:

Tranexamic acid can be used in any hemorrhagic condition of animals

Avoid In:

N/A

Contraindication Notes:

N/A

Tranexamic acid competitively and reversibly inhibits the activation of plasminogen via binding at several distinct sites, including four or five low-affinity sites and one high-affinity site, the latter of which is involved in its binding to fibrin. The binding of plasminogen to fibrin induces fibrinolysis - by occupying the necessary binding sites tranexamic acid prevents this dissolution of fibrin, thereby stabilizing the clot and preventing hemorrhage.

Albutrepenonacog alfa : Tranexamic acid may increase the thrombogenic activities of Albutrepenonacog alfa.
Alpha-1-proteinase inhibitor : Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Tranexamic acid.
Alteplase : The therapeutic efficacy of Tranexamic acid can be decreased when used in combination with Alteplase.
Aminocaproic acid: Tranexamic acid may increase the thrombogenic activities of Aminocaproic acid.
Andexanet alfa: Tranexamic acid may increase the thrombogenic activities of Andexanet alfa

Meat: 2days.

Milk: 2 days