Aject DS Vet

Applications: Abscess, Calf Diphtheria, Campylobacteriosis, Cystitis, Enteritis, Gastritis, Laryngitis, Mastitis, Mastitis-Metritis-Agalactia Syndrome, Nephritis, Pharyngitis, Pneumonia, Pyometra, Retention of placenta, Sinusitis, Skin and Soft Tissue infection, Stomatitis, Uterine Infection, Wound, bronchitis, salmonellosis, Arthritis, Black Quarter, Eczema, Calf Scour, Colibacillosis, Necrotic Enteritis, Infectious coryza, Fowl Cholera, Fowl Typhoid, Streptococcosis, Staphylococcosis
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Urinary and Reproductive System: Mastitis, Metritis, Pyometra, Retention of Placenta, Cystitis, Nephritis, Metritis-Mastitis-Agalactia (MMA) Syndrome.

Respiratory System: Pneumonia, Bronchitis, Calf Diphtheria, Sinusitis, Pharyngitis, Laryngitis

Digestive System: Calf Scour, Salmonellosis, Gastritis, Enteritis, Stomatitis, Campylobacteriosis

Musculo-skeletal System: Skin and Soft tissue infection, Abscess, Wound, Black quarter, Arthritis, Eczema 

Prevention of Secondary bacterial Infection.

Avoid In: Hypersensitivity

Beta-lactam antibiotic. Amoxicillin inhibits bacterial cell wall synthesis. Amoxicillin generally has a narrow spectrum of activity that includes streptococci, non–beta-lactamase–
producing staphylococci, and other gram-positive cocci and bacilli. 

Many Staphylococcus strains are resistant because of beta-lactamase production. Most enteric gram-negative Enterobacteriaceae bacilli are resistant. Susceptible gram-negative bacteria include some species of Proteus, Pasteurella multocida, and Histophilus spp. resistance among other gram-negative bacteria is common.

BACTERIOSTATIC ANTIMICROBIALS (e.g., chloramphenicol, erythromycin and other macrolides, tetracyclines, sulfonamides, etc.): Because there is evidence of in vitro antagonism between beta-lactam antibiotics and bacteriostatic antibiotics, use together has been generally not recommended in the past, but actual clinical importance is not clear and in doubt.
METHOTREXATE: Amoxicillin may decrease the renal excretion of MTX causing increased levels and potential toxic effects.
PROBENECID: Competitively blocks the tubular secretion of most penicillins, thereby increasing serum levels and serum half-lives.

Adverse effects with the penicillins are usually not serious and have a relatively low frequency of occurrence. Hypersensitivity reactions unrelated to dose can occur with these agents and can manifest as rashes, fever, eosinophilia, neutropenia, agranulocytosis, thrombocytopenia, leukopenia, anemias, lymphadenopathy, or full blown anaphylaxis.
When given orally, penicillins may cause GI effects (anorexia, vomiting, diarrhea). Because the penicillins may alter gut flora, antibiotic-associated diarrhea can occur and allow the proliferation of resistant bacteria in the colon (superinfections). Healthy dogs given oral amoxicillin had their gut flora altered with a shift in balance toward gram-negative bacteria that included resistant Enterobacteriaceae species

High doses or very prolonged use have been associated with neurotoxicity (e.g., ataxia in dogs). Although the penicillins are not considered hepatotoxic, elevated liver enzymes have been reported. Other effects reported in dogs include tachypnea, dyspnea, edema and tachycardia.

Penicillins have been shown to cross the placenta; safe use during pregnancy has not been firmly established, but neither have there been any documented teratogenic problems associated with these drugs. However, use only when the potential benefits outweigh the risks. In humans, the FDA categorizes this drug as category B for use during pregnancy.

25 days for meat, 96 hours for milk. Amoxicillin intramammary infusion: withdrawal time 12 days for meat, 60 hours for milk