Alurol Vet

• High Blood Uric Acid Level
• Gout

prevention and treatment of high blood uric acid level and gout, prevents deposition of urate crystal in kidney, serous membranes of liver, heart, air sac and joints of poultry.

The principle veterinary uses for allopurinol are for the prophylactic treatment of recurrent uric acid uroliths and hyperuricosuric calcium oxalate uroliths in dogs, particularly Dalmatians. It has also been used in an attempt to treat gout in pet birds and reptiles.
Allopurinol has been recommended as an alternative treatment for canine
Leishmaniasis. Although it appears to have clinical efficacy, it must be used for many months of treatment and does not apparently clear the parasite in most dogs at usual dosages. Allopurinol may also be useful for American Trypanosomiasis.

N/A

Allopurinol is contraindicated in patients who are hypersensitive to it or have previously developed a severe reaction to it. It should be used cautiously and with intensified monitoring in patients with impaired hepatic or renal function.
When used in patients with renal insufficiency, dosage reductions and increased monitoring are usually warranted.
Allopurinol does not appear to be effective in dissolving urate uroliths in dogs with portovascular anomalies.

Allopurinol and its metabolite, oxypurinol, inhibit the enzyme xanthine oxidase. Xanthine oxidase is responsible for the conversion of oxypurines (e.g., hypoxanthine, xanthine) to uric acid. Hepatic microsomal enzymes may also be inhibited by allopurinol. It does not increase the renal excretion of uric acid nor does it possess any anti-inflammatory or analgesic activity. 

Allopurinol is metabolized by Leishmania into an inactive form of inosine that is incorporated into the organism’s RNA leading to faulty protein and RNA synthesis.
Allopurinol, by inhibiting xanthine oxidase, can inhibit the formation of superoxide anion radicals, thereby providing protection against hemorrhagic shock and myocardial ischemia in laboratory conditions. The clinical use of the drug for these indications requires further study.

The following drug interactions have either been reported or are theoretical in humans or animals receiving allopurinol and may be of significance in
veterinary patients:

ANTICOAGULANT: Allopurinol prolongs the half life of the anticoagulant, dicoumarol.
DIURETICS: Concomitant use of Allopurinol and thiazide diuretics may contribute to the enhancement of Allopurinol toxicity.
CYTOTOXIC AGENT: Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agent has been reported among patients with neoplastic disease.
AMINOPHYLLINE or THEOPHYLLINE: Large doses of allopurinol may decrease metabolism thereby increasing their serum levels
AMOXICILLIN or AMPICILLIN: In humans, concomitant use with allopurinol has been implicated in increased occurrences of skin rashes; the veterinary significance of this interaction is unknown
AZATHIOPRINE or MERCAPTOPURINE: Allopurinol may inhibit metabolism and increase toxicity; if concurrent use is necessary, dosages of the antineoplastic/immunosuppressive agent should be reduced initially to 25–33% of their usual dose and then adjusted, dependent upon patient’s response
CHLORPROPAMIDE: Allopurinol may increase risks for hypoglycemia and hepato-renal reactions
CYCLOPHOSPHAMIDE: Increased bone marrow depression may occur in patients receiving both allopurinol and cyclophosphamide
CYCLOSPORINE: Allopurinol may increase cyclosporine levels
DIURETICS (Furosemide, Thiazides, Diazoxide, and Alcohol): Can increase uric acid levels
ORAL ANTICOAGULANTS (e.g., Warfarin): Allopurinol may reduce the metabolism of warfarin thereby increasing effect
TRIMETHOPRIM/SULFAMETHOXAZOLE: In a few human patients, thrombocytopenia has occurred when used with allopurinol
URICOSURIC AGENTS (e.g., Probenecid, Sulfinpyrazone): May increase the renal excretion of oxypurinol and thereby reduce xanthine oxidase inhibition; in treating hyperuricemia the additive effects on blood uric acid may, in fact, be beneficial to the patient
URINARY ACIDIFIERS (e.g., Methionine, Ammonium Chloride) May reduce the solubility of uric acid in the urine and induce urolithiasis

The most frequent adverse reaction to Allopurinol is skin rash such as, pruritic maculopapular skin eruptions, sometimes scaly or exfoliative.

Over dosage may cause diarrhea, abdominal pain and neurotoxicity.

Protect from light & keep in a cool and dry place. Keep out of reach of children.