Dellergen Vet

Promethazine has dual effects. It is used for treatment of allergy (antihistamine effect) and as an antiemetic (motion sickness). The efficacy for treating allergies in animals has not been established or studied in clinical trials. The uses in animals have been derived from empirical use and experience in humans. There are no well-controlled clinical studies or efficacy trials to document clinical effectiveness. Antihistamines have not been as effective for motion sickness in animals compared with other antiemetic agents.

Promethazine may produce antimuscarinic side effects, but these have not been reported from clinical use in animals.

Promethazine is a phenothiazine drug with strong antihistamine effects. Promethazine is used mostly for its antiemetic effects, for which it acts either via the antihistamine receptors or by blocking dopamine receptors associated with vomiting.

Promethazine has a risk of producing phenothiazine effects such as sedation and other side effects attributed to other phenothiazines. There also may be anticholinergic effects produced by the antimuscarinic properties in some individuals