Doxy-A Vet

Applications: Chronic Respiratory Disease (CRD), Colibacillosis, Fowl Cholera, Fowl Typhoid, Infectious coryza, Infectious Synovitis, Mycoplasmosis, salmonellosis, Chlamydia, Necrotic Enteritis

Tetracyclines generally act as bacteriostatic antibiotics and inhibit protein synthesis by reversibly binding to 30S ribosomal subunits of susceptible organisms, thereby preventing binding to those ribosomes of aminoacyl transfer-RNA. Tetracyclines also are believed to reversibly bind to 50S ribosomes and, additionally, alter cytoplasmic membrane permeability in susceptible organisms. In high concentrations, tetracyclines can also inhibit protein synthesis by mammalian cells. 

As a class, the tetracyclines have activity against most mycoplasma, spirochetes (including the Lyme disease organism), Chlamydia and Rickettsia. Against gram-positive bacteria, the tetracyclines have activity against some strains of staphylococcus and streptococci, but resistance by these organisms is increasing. Gram-positive bacteria that are usually covered by tetracyclines include: Actinomyces spp., Bacillus anthracis, Clostridium perfringens and tetani, Listeria monocytogenes and Nocardia. Among gram-negative bacteria that tetracyclines usually have in vitro and in vivo activity against, include Bordetella spp., Brucella, Bartonella, Haemophilus spp., Pasturella multocida, Shigella, and Yersinia pestis. Many or most strains of E. coli, Klebsiella, Bacteroides, Enterobacter, Proteus and Pseudomonas aeruginosa are resistant to the tetracyclines.
Doxycycline generally has very similar activity as other tetracyclines against susceptible organisms, but some strains of bacteria may be more susceptible to doxycycline or minocycline and additional in vitro testing may be required.

The following drug interactions have either been reported or are theoretical in
humans or animals receiving doxycycline and may be of significance in
veterinary patients:
ANTACIDS, ORAL: When orally administered, tetracyclines can chelate divalent or trivalent cations that can decrease the absorption of the tetracycline or the other drug if it contains these cations. Oral antacids, saline cathartics, or other GI products containing aluminum, calcium, magnesium, zinc, or bismuth cations are most commonly associated with this interaction. Doxycycline has a relatively low affinity for calcium ions, but it is recommended that all oral tetracyclines be given at least 1–2 hours before or after the cation-containing product.
BISMUTH SUBSALICYLATE, KAOLIN, PECTIN: May reduce absorption
IRON, ORAL: Oral iron products are associated with decreased tetracycline absorption, and administration of iron salts should preferably be given 3 hours before or 2 hours after the tetracycline dose.
PENICILLINS: Bacteriostatic drugs, like the tetracyclines, may interfere with bactericidal activity of the penicillins, cephalosporins, and aminoglycosides. There is a fair amount of controversy regarding the actual clinical significance of this interaction, however.
PHENOBARBITAL: May decrease doxycycline half-life and reduce levels
WARFARIN: Tetracyclines may depress plasma prothrombin activity and patients on anticoagulant (e.g., warfarin) therapy may need dosage

Store below 30° C and dry place, protected from light. Keep all medicines out of reach of children.