Ectorid Vet

Imidocarb is an aromatic diamidine. It inhibits nucleic acid metabolism in susceptible organisms and produces anticholinergic effects. It has antimicrobial activity against protozoal organisms, which accounts for its clinical use. It appears to particularly affect the erythrocyte stages of the parasite by inhibition of inositol entry into infected erythrocytes.

The manufacturer warns not use imidocarb in patients exposed to cholinesterase-inhibiting drugs, pesticides, or chemicals.

Allergic reactions may occur with beta-lactam antibiotics. With rapid infusion or in patients with renal insufficiency, neurotoxicity may occur. Neurotoxicity in animals has included tremors, nystagmus, and seizures. Nephrotoxicity is possible, but imipenem is combined with cilastatin to decrease renal metabolism. Vomiting and nausea are possible. IM injections can cause painful reactions

Dogs receiving a dosage of 9.9 mg/kg (1.5X labeled dose) showed signs of liver injury (slightly increased liver enzymes), pain and swelling at the injection site, and vomiting. Overdoses or chronic toxicity may present with cholinergic signs (vomiting, weakness, lethargy, salivation) or adverse changes in liver, kidney, lung, or intestinal function. Treatment with atropine may be useful to treat cholinergic signs associated with imidocarb.
The LD-50 in horses is reportedly 16 mg/kg.

Use cautiously in patients prone to seizures. Seizures may be more likely in
patients with renal failure.

Meat: 28 days.

Milk: 5 days.