Edecure Vet

 Indicated for the treatment of ascites, udder edema, pulmonary congestion, renal failure, acute non-inflammatory tissue edema etc. It also helps to excrete poisons or drug overdose by increasing urine flow. 

 Contraindicated to animal anuria, hypersensitivity, or seriously depleted electrolytes. 

 Furosemide increase urine volume by reducing the efficiency of sodium resorbing processes and so increase water loss from the body. 

Furosemide is a loop diuretic that inhibits the Na+/K+/2Cl–cotransporter in the ascending thick loop of Henle. It is often called a high-ceiling diuretic because it is more effective than other diuretics. Furosemide decreases the sodium, chloride, and potassium reabsorption from the tubule. Subsequently, these ions are retained in the renal tubule and presented to the distal nephron. Dilute urine is produced because water is retained in the tubule when it reaches the distal tubule. In addition, there is an associated urine loss of Mg2+ and Ca2+. An additional mechanism of action is via prostaglandin synthesis. Furosemide increases intrarenal prostaglandin production (e.g., PGI2), which increases renal blood flow. Synthesis of prostaglandins also may cause vasodilation in other tissues. Torsemide is another diuretic in the same class as furosemide. It has greater potency than furosemide and can be used in refractory cases.

Pharmacokinetics: The plasma half-life in animals is short (1.5–3 hours); therefore, this is a short-acting drug, with a maximum onset of effect of 1–2 hours and a duration of 2–4 hours. Oral absorption can be highly variable but in dogs is as high as 77%. SQ absorption is as high as other injectable routes. In horses, oral absorption is so low that this is not a viable method of administration.

ACE INHIBITORS (e.g., enalapril, benazepril): Increased risks for hypotension, particularly in patients who are volume or sodium depleted secondary to diuretics
AMINOGLYCOSIDES (gentamicin, amikacin, etc.): Increased risk for ototoxicity
AMPHOTERICIN B: Loop diuretics may increase the risk for nephrotoxicity development; hypokalemia
CORTICOSTEROIDS: Increased risk for GI ulceration; hypokalemia
DIGOXIN: Furosemide-induced hypokalemia may increase the potential for digoxin toxicity
INSULIN: Furosemide may alter insulin requirements
MUSCLE RELAXANTS, NON-DEPOLARIZING (e.g., atracurium, tubocurarine): Furosemide may prolong neuromuscular blockade
PROBENECID: Furosemide can reduce uricosuric effects
SALICYLATES: Loop diuretics can reduce the excretion of salicylates
SUCCINYLCHOLINE: Furosemide may potentiate
THEOPHYLLINE: Pharmacologic effects of theophylline may be enhanced when used with furosemide

 Common side effects: Increased urination alkalosis, uric acid retention and may rarely produce acute gout, hyperglycemia & glycosuria. 

Rare side effects: Diarrhea or constipation, weakness, collapse, head tilt, balance problems, electrolyte imbalance, lack of urine production, or a racing heart rate. Fluid & electrolyte (esp. hyponatremia) abnormalities, others included: ototoxicity, GI distress, hematologic effects, ototoxicity, weakness, & restlessness 

 Acute overdosage may cause electrolyte and water balance problems, CNS effects (lethargy to coma and seizures) and cardiovascular collapse. Treat supportively and symptomatically if necessary. 

 Can be used in Pregnancy and lactating animals. However, risk & necessity should be considered during administration in pregnant & lactating animal.

 Do not mix with other medicines. Animals with pre-existing electrolyte or water balance abnormalities, impaired hepatic function. 

 Meat & Milk: Meat & milk must not be consumed up to 2 days after administration of this medicine. Egg: Not known. 

 Store below 300 C temperature and dry place, protected from light. Keep all medicines out of reach of children.