Itracon Vet

• Aspergillosis
• Candidiasis
• Thrush
• Crop Mycosis
• Sour Crop

Itraconazole may have use in veterinary medicine in the treatment of systemic mycoses, including aspergillosis, cryptococcal meningitis, blastomycosis, and histoplasmosis. Itraconazole is probably more effective than ketoconazole, but is significantly more expensive. It may also be useful for superficial candidiasis or dermatophytosis. Itraconazole does not have appreciable effects (unlike ketoconazole) on hormone synthesis and may have fewer side effects than ketoconazole in small animals.
It is considered by many to be the drug of choice for treating blastomycosis, unless moderate or severe hypoxemia is present (than amphotericin B).
In horses, itraconazole may be useful in the treatment of sporotrichosis and Coccidioides immitis osteomyelitis.

N/A

Hepatic and Renal impaired patients.

Itraconazole is a fungistatic triazole compound. Triazole-derivative agents, like the imidazoles (clotrimazole, ketoconazole, etc.), presumably act by altering the cellular membranes of susceptible fungi, thereby increasing membrane permeability and allowing leakage of cellular contents and impaired uptake of purine and pyrimidine precursors. Itraconazole has efficacy against a variety of pathogenic fungi, including yeasts and dermatophytes. In vivo studies using laboratory models have shown that itraconazole has fungistatic activity against many strains of Candida, Aspergillus, Cryptococcus, Histoplasma, Blastomyces, and Trypanosoma cruzi. Itraconazole has immune-suppressing activity, probably via suppressing Tlymphocyte proliferation

The following drug interactions have either been reported or are theoretical in humans or animals receiving itraconazole and may be of significance in
veterinary patients:
AMPHOTERICIN B: Lab animal studies have shown that itraconazole used concomitantly with amphotericin B may be antagonistic against Aspergillus or Candida; the clinical importance of these findings is not yet clear
ANTACIDS: May reduce oral absorption of itraconazole; administer itraconazole at least 1 hour before or 2 hours after antacids
BENZODIAZEPINES (alprazolam, diazepam, midazolam, triazolam): Itraconazole may increase levels
BUSPIRONE: Plasma concentrations may be elevated
BUSULFAN: Itraconazole may increase levels
CALCIUM-CHANNEL BLOCKING AGENTS (amlodipine, verapamil): Itraconazole may increase levels
CISAPRIDE: Itraconazole may increased cisapride levels and possibility for toxicity; use together contraindicated in humans
CLOMIPRAMINE: Itraconazole may decrease metabolism and increase clomipramine levels
CORTICOSTEROIDS: Itraconazole may inhibit the metabolism of corticosteroids; potential for increased adverse effects
CYCLOPHOSPHAMIDE: Itraconazole may inhibit the metabolism of cyclophosphamide and its metabolites; potential for increased toxicity
CYCLOSPORINE: Increased cyclosporine levels
DIGOXIN: Itraconazole may increase digoxin levels; use together considered contraindicated in humans
FENTANYL/ALFENTANIL: Itraconazole may increase fentanyl or alfentanil levels
H2-BLOCKERS (ranitidine, famotidine, etc.): Increased gastric pH may reduce itraconazole absorption
IVERMECTIN: Itraconazole may increase risk for neurotoxicity
MACROLIDE ANTIBIOTICS (erythromycin, clarithromycin): May increase itraconazole concentrations
PHENOBARBITAL/PHENYTOIN: May decrease itraconazole levels
PROTON-PUMP INHIBITORS (omeprazole, etc.): Increased gastric pH may reduce itraconazole absorption
QUINIDINE: Increased risk for quinidine toxicity
RIFAMPIN: May decrease itraconazole levels; itraconazole may increase rifampin levels
SULFONYLUREA ANTIDIABETIC AGENTS (e.g., glipizide, glyburide):
Itraconazole may increase levels; hypoglycemia possible 
Vincristine/Vinblastine: Itraconazole may inhibit vinca alkaloid metabolism and increase levels
WARFARIN: Itraconazole may cause increased prothrombin times in patients receiving warfarin or other coumarin anticoagulants

Vomition, Anorexia, Body weight loss

For layer: Not recommended 

Protect from light & keep in a cool and dry place. Keep out of the reach of children.