Inj.

Nilacid-Vet

Drug Class: Alkalinizer

Generic Drug: Sodium Bicarbonate

View Alternative Brand Names (2)

Manufacturer: Square Pharmaceuticals Ltd.

Basic information

Generic Drug

Sodium Bicarbonate

Route of Administration

IV

Strength / Concentration

75 mg/ml

Presentation and price

100 ml vial

Taka

Dose and dosage

Cattle

1.78-4.46 ml/kg body weight or 100 ml/ 22-56 kg body weight; intravenously or 1.78-4.46 ml/kg body weight.
Buffalo

1.78-4.46 ml/kg body weight or 100 ml/ 22-56 kg body weight; intravenously or 1.78-4.46 ml/kg body weight.
Sheep

1.78-4.46 ml/kg body weight or 100 ml/ 22-56 kg body weight; intravenously or 1.78-4.46 ml/kg body weight.
Goat

1.78-4.46 ml/kg body weight or 100 ml/ 22-56 kg body weight; intravenously or 1.78-4.46 ml/kg body weight.
Horse

1.78-4.46 ml/kg body weight or 100 ml/ 22-56 kg body weight; intravenously or 1.78-4.46 ml/kg body weight.

Applications: Metabolic Acidosis, Carbohydrate Engorgement / Lactic Acidosis, Lactic Acidosis, Barbiturate Toxicity, Severe Diarrhea

 Sodium Bicarbonate is contraindicated in animal that are losing chloride ion from body by vomiting and receiving diuretics, congestive heart failure or other edematous or sodium-retaining states, as well as in patients with oliguria or anuria. 

 Sodium Bicarbonate is dissociated to provide bicarbonate ion, increases plasma bicarbonate which neutralizes hydrogen ion and raises blood and urinary pH and reverses the clinical manifestations of metabolic acidosis 

The following drug interactions have either been reported or are theoretical in humans or animals receiving sodium bicarbonate and may be of significance in veterinary patients:
ANTICHOLINERGIC AGENTS: Concomitant oral sodium bicarbonate may reduce absorption; administer separately
AZOLE ANTIFUNGALS (ketoconazole, itraconazole): Concomitant oral sodium bicarbonate may reduce absorption; administer separately
CIPROFLOXACIN; ENROFLOXACIN: The solubility of ciprofloxacin and enrofloxacin is decreased in an alkaline environment; patients with alkaline urine should be monitored for signs of crystalluria
CORTICOSTEROIDS: Patients receiving high dosages of sodium bicarbonate and ACTH or glucocorticoids may develop hypernatremia
DIURETICS (e.g., thiazides, furosemide): Concurrent use of sodium bicarbonate in patients receiving potassium-wasting diuretics may cause hypochloremic alkalosis
EPHEDRINE: When urine is alkalinized by sodium bicarbonate, excretion may be decreased
HISTAMINE2 BLOCKING AGENTS (e.g., cimetidine, ranitidine): Concomitant oral sodium bicarbonate may reduce absorption; administer separately
IRON PRODUCTS: Concomitant oral sodium bicarbonate may reduce absorption; administer separately
ORAL MEDICATIONS: Because oral sodium bicarbonate can either increase or reduce the rate and/or extent of absorption of many orally administered drugs, it is recommended to avoid giving other drugs within 1– 2 hours of sodium bicarbonate
QUINIDINE: When urine is alkalinized by sodium bicarbonate, excretion may be decreased
SALICYLATES: When urine is alkalinized by sodium bicarbonate, excretion of weakly acidic drugs may be increased
SUCRALFATE: Oral sodium bicarbonate may reduce the efficacy of sucralfate if administered concurrently
TETRACYCLINES: Concomitant oral sodium bicarbonate may reduce absorption; administer separately

 Common side effects: Metabolic alkalosis, hypokalemia, hypocalcemia. 

Rare side effects: Hyperirritability or tetany 

 Overdose for a long period can result in metabolic alkalosis, Muscular twitching and hypernatremia. 

 Should be used with great care as hypertonic solution & should not use if it contains a precipitate. Incompatible with calcium containing solution. Not for intravenous injection in dogs & cats 

Store below 300 C temperature and dry place, protected from light. Keep all medicines out of reach of children