Peravet

 Poultry: used for the treatment of infestation caused by round worm such as Ascaridia galli, Heterakis gallinarum, Syngamus trachea etc. 

 Cattle, Buffalo, Horse, Sheep, Goat, Dog & Cat:  used for the treatment of infestation caused by round worm. 

Piperazine should be considered contraindicated in patients with chronic liver or kidney disease, and those with gastrointestinal hypomotility. There is some evidence in humans that high-dose piperazine may provoke seizures in patients with a history of seizures, or with renal disease.

Piperazine is one of the oldest and still widely used antiparasitic drugs used in animals. Piperazine produces neuromuscular blockade in parasites through selective antagonism of GABA receptors, resulting in opening of chloride channels, hyperpolarization of parasite membrane, and paralysis of worms. Efficacy is limited primarily to roundworms. In horses, it is active against small strongyles and roundworms.

Piperazine is thought to exert “curare-like” effects on susceptible nematodes, thereby paralyzing or narcotizing the worm and allowing it to be passed out with the feces. The neuromuscular blocking effect is believed to be caused by blocking acetylcholine at the myoneural junction. In ascarids, succinic acid production is also inhibited.

The following drug interactions have either been reported or are theoretical in humans or animals receiving piperazine and may be of significance in veterinary patients:
CHLORPROMAZINE: Although data conflicts, piperazine and chlorpromazine may precipitate seizures if used concomitantly
LAXATIVES: The use of purgatives (laxatives) with piperazine is not recommended as the drug may be eliminated before its full efficacy is established
PYRANTEL/MORANTEL: Piperazine and pyrantel/morantel have antagonistic modes of action and should generally not be used together

Piperazine is remarkably safe in all species but can cause ataxia, muscle tremors, and changes in behavior.

Acute massive overdosage can lead to paralysis and death, but the drug is generally considered to have a wide margin of safety. 

If used in horses with heavy infestations of P. equorum, rupture or blockage of intestines is possible due to the rapid death and detachment of the worm.

Meat: 1.5 days

Milk: 1 day

Store below 30° C temperature and dry place, protected from light. Keep all medicines out of reach of children.