Tifur Vet

In cattle for treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. It is also indicated for treatment of acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus. In swine for treatment/control of swine bacterial respiratory disease (swine bacterial pneumonia) associated with Actinobacillus (Haemophilus) pleuropneumoniae, Pasteurella multocida, Salmonella choleraesuis and
Streptococcus suis. In sheep/goats for treatment of sheep/caprine respiratory disease (sheep/goat pneumonia) associated with Mannheimia haemolytica and Pasteurella multocida. 

In horses for treatment of respiratory infections in horses associated with Streptococcus zooepidemicus. 

In dogs for the treatment of canine urinary tract infections associated with E. coli and Proteus mirabilis.
In day old chicks/poults for the control of early mortality, associated with E. coli organisms susceptible to ceftiofur.

Ceftiofur is a 3rd generation cephalosporin antibiotic active against a variety of gram-positive and gram-negative bacteria and like other cephalosporins inhibits bacteria cell wall synthesis, is usually bactericidal and is a timedependent antibiotic.
Ceftiofur is rapidly cleaved into furoic acid and desfuroylceftiofur, which is active. Desfuroylceftiofur inhibits cell wall synthesis (at stage three) of susceptible multiplying bacteria and exhibits a spectrum of activity similar to that of cefotaxime. It has a broad range of in vitro activity against a variety of pathogens, including many species of Pasturella, Streptococcus, Staphylococcus, Salmonella, and E. coli.

Adverse effects with the cephalosporins are usually not serious and have a relatively low frequency of occurrence. The use of ceftiofur may result in some signs of immediate and transient local pain to the animal. Following subcutaneous administration of ceftiofur sodium in the neck, small areas of discoloration at the site may persist beyond five days, potentially resulting in trim loss of edible tissues at slaughter. Localized post-injection bacterial infections may result in abscess formation in cattle. Attention to hygienic procedures can minimize their occurrence.

Cephalosporin overdoses are unlikely to cause significant problems other than
GI distress, but other effects are possible

Cephalosporins have been shown to cross the placenta and safe use of them during pregnancy have not been firmly established, but neither have there been any documented teratogenic problems associated with these drugs. However, use only when the potential benefits outweigh the risks.

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