Tylochem Vet

In cattle, tylosin is used for treatment of BRD caused by Mannheimia spp., P. multocida, and H. somni. It is used for interdigital necrobacillosis (foot rot) in cattle caused by F. necrophorum or B. melaninogenicus. In pigs, it is used for treatment of swine arthritis caused by Mycoplasma hyosynoviae, swine pneumonia caused by Pasteurella spp., swine erysipelas caused by Erysipelothrix rhusiopathiae, swine dysentery associated with Serpulina (Treponema) hyodysenteriae, and proliferative enteropathy caused by L. intracellularis. For treatment in pigs, it is also added to feed (type A–medicated feed article) or drinking water. In small animals, it is used for gram-positive soft tissue and skin infections. However, this use is uncommon, and the most frequent use in dogs is for treatment of diarrhea, referred to as antibiotic-responsive diarrhea, that has not responded to other treatments. The etiology of the diarrhea is not known but may be caused by Clostridium or Campylobacter spp. For this use, the powdered formulation (swine formulation) has been added to food daily for maintenance.

Do not administer orally to rodents or rabbits. Do not administer to horses.

to 50S ribosome and inhibits protein synthesis) and exhibits a similar spectrum of activity. It is a bacteriostatic antibiotic. Tylosin may also have immunomodulatory effects on cell-mediated immunity. In dogs, tylosin increases concentrations of enterococci (Enterococcus fecalis) in the jejunum. Enterococci are thought to have probiotic effects.

Clostridium and Campylobacter spp. are usually susceptible. The spectrum also includes the bacteria that cause BRD. E. coli and Salmonella spp. are resistant. In pigs, Lawsonia intracellularis is usually susceptible.

Drug interactions with tylosin have not been well documented. It has been suggested that tylosin may increase digoxin blood levels with resultant toxicity.
It is suggested to refer to the erythromycin monograph for more information on potential interactions.

Tylosin may cause diarrhea in some animals. However, for oral treatment for colitis in dogs, it has been administered for several months with safety. Skin reactions have been observed in pigs. Oral administration to horses has been fatal.

In a system evaluating the safety of drugs in canine and feline pregnancy (Papich 1989), this drug is categorized as in class: B (Safe for use if used cautiously. Studies in laboratory animals may have uncovered some risk, but these drugs appear to be safe in dogs and cats or these drugs are safe if they are not administered when the animal is near term.)

Avoid IV administration. Do not inject more than 10 mL in one IM site to avoid
local reactions.

Meat: 21days

Milk: 7 days