Amprium-Vet

Amprolium has good activity against Eimeria tenella and E. acervulina in poultry and can be used as a therapeutic agent for these organisms. It only has marginal activity or weak activity against E. maxima, E. mivati, E. necatrix, or E. brunetti. It is often used in combination with other agents (e.g., ethopabate) to improve control against those organisms.
In cattle, amprolium used for the treatment and prevention of E. bovis and E. zurnii in cattle and calves.
Amprolium has been used in dogs, swine, sheep, and goats for the control of coccidiosis,

Do not administer to debilitated animals.

Antiprotozoal drug. This drug is a vitamin B1 or thiamine structural analogue. By mimicking its structure, amprolium competitively inhibits thiamine utilization by the parasite. Prolonged high dosages can cause thiamine deficiency in the host; excessive thiamine in the diet can reduce or reverse the anticoccidial activity of the drug. Amprolium is thought to act primarily upon the first generation schizont in the cells of the intestinal wall, preventing differentiation of the metrozoites. It may suppress the sexual stages and sporulation of the oocysts.

THIAMINE: Exogenously administered thiamine in high doses may reverse or reduce the efficacy of amprolium

In dogs, neurologic disturbances, depression, anorexia, and diarrhea have been
reported but are rare and are probably dose-related

Toxicity is observed only at high doses. CNS signs are caused by thiamine deficiency, which may be reversed by adding thiamine to the diet.

Usually administered as feed additive to livestock

Store below 25° C temperature and dry place, protected from light. Keep all medicines out of reach of children.