Oint.
Mastanil Vet
Drug Class: Antibiotics (Anti-mastitis prep.)
Manufacturer: Techno Drugs Ltd.
Basic information
Generic Drug
Route of Administration
Strength / Concentration
Presentation and price
7.5 gm
Dose and dosage
After complete milking, 1 syringe/affected teat should be administered.
After complete milking, 1 syringe/affected teat should be administered.
- Mastitis
- Acute Mastitis
N/A
N/A
N/A
Gentamicin is an aminoglycoside antibiotic. Like other aminoglycosides, the action is to inhibit bacteria protein synthesis via binding to 30S ribosome. Through this action, it causes a misreading of the genetic code and inhibits bacterial protein synthesis. Another mechanism important for gram-negative bacteria is to disrupt the cell surface biofilm, particularly on gram-negative bacteria, to produce disruption, loss of cell wall integrity, and a rapid bactericidal effect. Magnesium and calcium are important to cross-bridge adjacent lipopolysaccharide molecules. Positive-charged aminoglycosides competitively displace Ca2+ and Mg2+ and destabilize the bacteria outer membrane. Therefore, death of the bacteria is caused by a cell surface effect rather than inhibition of the ribosome. This property is not as prominent for gram-positive bacteria unless administered with a cell wall–disrupting agent such as vancomycin or a beta-lactam antibiotic.
Milk: 48 hours