Clotrimazole (Topical)

N/A

All dermatomycoses due to dermatophytes (e.g.Trichophyton species). All dermatomycoses due to yeasts (Candida species). Dermatomycoses due to moulds and other fungi. Skin diseases showing superinfections with these fungi. Some examples of skin infections ... Read more All dermatomycoses due to dermatophytes (e.g.Trichophyton species). All dermatomycoses due to yeasts (Candida species). Dermatomycoses due to moulds and other fungi. Skin diseases showing superinfections with these fungi. Some examples of skin infections included in above points are interdigital mycoses (e.g. athlete's foot), paronychias (associated with nail mycoses), mycoses in skin folds, Candida vulvitis, Candida balanitis, Pityriasis versicolor, erythrasma.

N/A

Hypersensitivity to Clotrimazole.

Clotrimazole acts primarily by damaging the permeability barrier in the cell membrane of fungi. Clotrimazole causes inhibition of ergosterol biosynthesis, an essential constituent of fungal cell membranes. If ergosterol synthesis is either completely or partially inhibited, the cell is no longer able to construct an intact and functional cell membrane. Because ergosterol directly promotes the growth of fungal cells in a hormone‐like fashion, rapid onset of the above events leads to dose-dependent inhibition of fungal growth.Though decreased ergosterol, due to the inhibition of lanosterol 14-demethylase (also known as CYP51) is accepted to be primarily responsible for the antimycotic properties of clotrimazole, this drug also shows other pharmacological effects. These include the inhibition of sarcoplasmic reticulum Ca2+ ATPase, depletion of intracellular calcium, and blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels. The action of clotrimazole on these targets accounts for other effects of this drug that are separate from its antimycotic activities.

No information is available.

When applied topically, Clotrimazole is well tolerated.With external application, systemic effects are not observed. Local irritation or burning sensation may occur in a very few cases but these symptoms are not considered harmful.

It is recommended that Clotrimazole should be used in pregnancy only when considered necessary by the physician.