Clotrimazole (Vaginal suppository)

• Vaginitis

Clotrimazole vaginal suppository is used in candidal vaginitis.

N/A

Clotrimazole is contraindicated for patients who are hypersensitive to Clotrimazole.

Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds and bacteroids. Clotrimazole is also active against certain gram-positive bacteria especially Staphylococci and Tricomonas. Like other imidazoles, Clotrimazole alters the permeability of fungal cell walls by interfering with cell wall lipids. At fungi static levels the main effect is inhibition of ergosterol synthesis but at higher concentrations there is an additional mechanism of membrane damage unrelated to sterol synthesis.

Occasional skin irritation or burning sensation may occur in a very few cases which are not considered harmful.

Clotrimazole is very poorly absorbed into the blood and the body after application to the skin or the vagina. Studies in women in their second or third trimesters have demonstrated no ill effects. It is not known if Clotrimazole is secreted in breast milk. Clotrimazole suppository can be used during pregnancy, but only under the supervision of a Physician.

Constituents of the vaginal suppository may be incompatible with rubber in both contraceptive condoms and diaphragms. During period this treatment won't have good result. Avoid oral or ophthalmic use.

Clotrimazole vaginal suppository is not recommended for paediatric use.