Generic medicine
Erdosteine
Erdosteine is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.
Clinical notes
Applications:
- Chronic obstructive pulmonary disease (COPD)
Indication Notes:
Erdosteine is a mucolytic drug used in the treatment of acute and chronic respiratory diseases. It also improves the symptoms associated with short episodes of chronic bronchitis.
Avoid In:
N/A
Contraindication Notes:
It is contraindicated to patients who have hypersensitivity to Erdosteine. It should not be used in patients with creatinine clearance <25 ml/min, or with severe liver failure.
Erdosteine is a prodrug that is metabolised into N-thiodiglycolyl-homocysteine whereby free thiol groups are formed leading to the opening of the disulphide bonds of the bronchial mucoproteins, thus reducing the viscosity of mucus and purulent sputum. It also antagonises the local formation of free radicals and inhibits elastase enzyme activity and bacterial adhesion to epithelial cells.
Common side effect is epigastric pain. Other side effects include headache, cold, taste alterations, nausea, vomiting, diarrhea, angioedema and other skin allergic reactions.
The use of Erdosteine in pregnant or breast-feeding women is not recommended.
It should be used with caution in mild liver failure. In that case, should not exceed a dose of 300 mg per day.
Renal Impairment: CrCl <25 ml/min: Contraindicated.Hepatic Impairment: Mild to moderate: Max: 300 mg daily. Severe: Contraindicated.
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