Meclizine Hydrochloride

N/A

Meclizine Hydrochloride is indicated in nausea, vomiting, motion sickness, vertigo.

N/A

Meclizine is contraindicated in patients hypersensitive to Meclizine or any of its excipeints.

Meclizine has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Meclizine has an onset of action of 30 to 60 minutes, depending on dosage; their duration of action is 12 to 24 hours.

Meclizine may increase the toxicity with CNS depressants, neuroleptics and anticholinergic. Alcohol, sedatives and tranquilizers can increase the drowsiness of the patient.

Common side effects are Drowsiness, dry mouth, and on rare occasions, blurred vision have been reported.

Symptoms: Extreme excitability, seizures, drowsiness and hallucinations. Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis.

Meclizine shows no risk of birth defects or abnormalities when administered during pregnancy. Although Meclizine may excrete into the milk, it causes no harm in nursing babies.

Patients with asthma, bronchitis, emphysema, enlarged prostate, glaucoma or urinary tract blockage should take Meclizine (like other antiemetics) with caution.