Melatonin

• Osteoporosis

Melatonin is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag.Insomnia: Melatonin helps to induce sleep in people with- Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) ... Read moreMelatonin is used for numerous conditions but is showing the most promise in the short-term regulation of sleep patterns, including jet lag.Insomnia: Melatonin helps to induce sleep in people with- Disrupted circadian rhythms (such as those suffering from jet lag or poor vision or those who work the night shift) Low melatonin levels (such as some elderly and individuals with schizophrenia) Children with learning disabilities who suffer from insomnia. Osteoporosis: Melatonin stimulates cells called osteoblasts that promote bone growth.In Menopause: Melatonin helps peri- or postmenopausal women to regulate sleep patterns.Eating disorders: Melatonin levels may play a role in the symptoms of anorexia.Attention Deficit Hyperactivity Disorder (ADHD): it may be effective in managing sleep disturbances in children with this condition. AndSarcoidosis

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Melatonin should not be used by patients who have autoimmune diseases.

After administration, melatonin binds with its receptors. Two types of melatonin receptor subtypes - MT1 & MT2 have been identified in humans. Melatonin receptors are found in the brain and some peripheral organs. The MT1 subtype is present in the pars tuberalis of the pituitary gland and the suprachiasmatic nuclei of the hypothalamus. The MT2 subtype is mainly present in the retina. Increased level of Melatonin initiates neural & endocrine signals to optimize the levels of neurotransmitters e.g. increased serotonin, increased GABA & decreased dopamine, which induces & sustains sleep, as well as, maintains the body's circadian rhythm.

Antidepressant Medications: Melatonin reduces the antidepressant effects of desipramine and fluoxetine. In addition, fluoxetine leads to measurable depletion of melatonin in people.Antipsychotic Medications: People with schizophrenia and tardive dyskinesia taking antipsychotic medications with melatonin has significantly reduced mouth movements compared to those who did not take the supplements.Benzodiazepines: The combination of melatonin and triazolam improves sleep quality. In addition, there have been a few reports suggesting that melatonin supplements may help individuals stop using long-term benzodiazepine therapy.Blood Pressure Medications: Melatonin may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease melatonin levels. The use of beta-blockers (propranolol, acebutolol, atenolol, labetalol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce melatonin production in the body.Blood-Thinning Medications, Anticoagulants: Melatonin may increase the risk of bleeding from anticoagulant medications such as warfarin.Interleukin-2: In one study of 80 cancer patients, the use of melatonin in conjunction with interleukin-2 led to more tumor regression and better survival rates than treatment with interleukin-2 alone.Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs such as ibuprofen may reduce the levels of melatonin in the blood.Steroids and Immunosuppressant Medications: People should not take melatonin with corticosteroids or other medications used to suppress the immune system because the supplement may cause them to be ineffective.Tamoxifen: Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and melatonin may benefit certain patients with breast and other cancers.Other Substances: Caffeine, tobacco, and alcohol can all diminish levels of melatonin in the body while cocaine and amphetamines may increase melatonin production.

Possible adverse effects include headache and depression. Drowsiness may be experienced within 30 minutes after taking melatonin and may persist for 1 hour and thus may affect driving skills.

There is little or no evidence of any major toxicities with melatonin,even at high doses.

Information regarding safety and efficacy in pregnancy and lactation is not available.

Caffeine and fluvoxamine may increase the effects of melatonin, while melatonin may decrease the antihypertensive effect of nifedipine.