Naproxen Sodium

N/A

Naproxen is indicated for the relief of sign and symptoms of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendonitis, bursitis & acute gout. It is also indicated for the management of primary dysmenorrhea & pain.

N/A

Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery.

Naproxen is a non steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic & antipyretic properties. It is rapidly absorbed from the gastrointestinal tract and achieves 95% bioavailability.

ACE inhibitors: diminish the antihypertensive effect of ACE inhibitors.Antacids & Sucralfate: delay the absorption of Naproxen. Aspirin: increase adverse effects.Diuretics: reduce the natriuretic effect of Furosemide and Thiazides.Methotrexate: enhance the toxicity of Methotrexate.Warfarin: increase the risk of GI bleeding.Selective Serotonin Reuptake Inhibitors (SSRI): increase the risk of GI bleeding.

Most frequently reported side effects include following: Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia. Central Nervous System: Headache, vertigo, drowsiness. Dermatological: Pruritus (itching), purpura. Cardiovascular: Edema, palpitation. Others: Visual disturbances, hearing disturbances.

US FDA pregnancy category of Naproxen is C. So, Naproxen should be avoided in pregnancy & lactation unless the potential benefits to the other outweigh the possible risks to the fetus.