Proanthocyanidins

• Venous thrombosis

Chronic venous insufficiency (edema), thrombosis (blood clot), diabetes and its complications, retinopathy, hypertension (high blood pressure) and its complications, allergy, asthma, endometriosis (premenstrual pain caused by endometrial tissue in places other than the uterus) and dysmenorrhea (painful menstruation), osteoarthritis, skin disorders & melasma (a dark pigmentation of the skin).

N/A

There are no known contraindications for Proanthocyanidins.

French maritime pine bark extract is made by extraction of the outer bark of Pinus pinaster. Recent research suggests significant antioxidant activity is primarily based on its proanthocyanidin content. Proanthocyanidins prevents the oxidation of LDL cholesterol, protects the DNA from free-radical damage, prevents stress-related blood clotting without increasing bleeding risk, increases nitric oxide synthesis leading to vasodilation, has profound anti-inflammatory activity, protects the skin from sun damage, dramatically improves wound healing while decreasing scarring, boosts many aspects of immune system function, and also lowers blood sugar while stimulating fat tissue breakdown.

There is no reported information of drug interaction resulting from simultaneous intake of Proanthocyanidins with other drugs.

No serious side effects have been reported. To avoid gastric upset, diarrhea & constipation, Proanthocyanidins should be taken with meals. Minor adverse effects including headache and dizziness may occur.

As a general precaution, pregnant women should not take Proanthocyanidins within the first 3 months of pregnancy. Safety trials have demonstrated absence of mutagenic and teratogenic effects, no perinatal toxicity, and no negative effects on fertility. There are no adequate and well-controlled studies of Proanthocyanidins in children under the age of 6 years.