Generic medicine

Prochlorperazine Maleate

Prochlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. ... Read moreProchlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility). Acute mania. For the short-term treatment of generalized non-psychotic anxiety.

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10

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Clinical notes

Applications:

N/A

Indication Notes:
Prochlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. ... Read moreProchlorperazine Maleate is indicated- To control severe nausea and vomiting caused by radiation therapy, cancer chemotherapy, surgery, and other conditions. Relieving nausea, vomiting, and attacks of dizziness or spinning sensations (vertigo) associated with Meniere's disease and other inner ear disorders. For the treatment of psychotic illness such as schizophrenia (hallucinations and hostility). Acute mania. For the short-term treatment of generalized non-psychotic anxiety.
Avoid In:

N/A

Contraindication Notes:
Hypersensitivity to prochlorperazine or any component of the formulation, severe CNSdepression; coma; should not be used in children <2 years of age or <10 kg.
Prochlorperazine is a dopamine & histamine antagonist. The mechanism of antiemetic activity is due to the blockade of histamine H, & dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. It also has a weak anticholinergic effect and prevents acid reflux by increasing the tone of the lower oesophageal sphincter.
Alcohol, barbiturate & other sedatives may increase the CNS depressant action. Some drugs like Antacids, antiparkinson's drug, lithium may interfere the absorption of Prochlorperazine. This drug may interfere with the plasma concentration of Propanolol and Phenobarbital.
Drowsiness; jaw, neck, and back muscle spasms; fine worm-like tongue movements; rhythmic face, mouth, or jaw movements; slow or difficult speech; difficulty swallowing; restlessness and pacing; tremors; shuffling walk; skin rash; yellowing of the skin or eyes.
Symptoms of overdose include deep sleep, coma, extrapyramidal symptoms, abnormal involuntary muscle movements, and hypotension.
No evidence of adverse effects of this drug has been reported during pregnancy & lactation.
Caution should be taken while performing tasks that require alertness, such as driving or using machinery. The use of alcohol can cause extreme drowsiness. This medication may increase sensitivity to sunlight. Prolonged sun exposure should be avoided and sunscreen and protective clothing should be taken when anybody is exposed to the sun. This medication can reduce sweating making it more susceptible to heatstroke.

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