Generic medicine

Progesterone (Capsule)

Progesterone softgel capsule is indicated in- Maintenance of Pregnancy in cases of Threatened / Recurrent abortion. Luteal support during IUI and ART procedures IVF-ET. Luteal support in cases of proven luteal phase insufficiency. Along with estrogen in post-menopausal hormone replacement therapy (HRT) either in sequential or in continuous regimen. ... Read moreProgesterone softgel capsule is indicated in- Maintenance of Pregnancy in cases of Threatened / Recurrent abortion. Luteal support during IUI and ART procedures IVF-ET. Luteal support in cases of proven luteal phase insufficiency. Along with estrogen in post-menopausal hormone replacement therapy (HRT) either in sequential or in continuous regimen. To prevent endometrial hyperplasia where endogenous estrogen is present. As progesterone challenge test in secondary amenorrhoea. For cycle control along with estrogen therapy. Dysfunctional uterine bleeding (DUB) Premenstrual tension. Endometriosis. Oocyte donation programme. Benign mastopathy.

Brands

2

Categories

1

Browse brands Open class

Clinical notes

Applications:

N/A

Indication Notes:
Progesterone softgel capsule is indicated in- Maintenance of Pregnancy in cases of Threatened / Recurrent abortion. Luteal support during IUI and ART procedures IVF-ET. Luteal support in cases of proven luteal phase insufficiency. Along with estrogen in post-menopausal hormone replacement therapy (HRT) either in sequential or in continuous regimen. ... Read moreProgesterone softgel capsule is indicated in- Maintenance of Pregnancy in cases of Threatened / Recurrent abortion. Luteal support during IUI and ART procedures IVF-ET. Luteal support in cases of proven luteal phase insufficiency. Along with estrogen in post-menopausal hormone replacement therapy (HRT) either in sequential or in continuous regimen. To prevent endometrial hyperplasia where endogenous estrogen is present. As progesterone challenge test in secondary amenorrhoea. For cycle control along with estrogen therapy. Dysfunctional uterine bleeding (DUB) Premenstrual tension. Endometriosis. Oocyte donation programme. Benign mastopathy.
Avoid In:

N/A

Contraindication Notes:
Hypersensitivity, hepatic dysfunction, undiagnosed vaginal bleeding, porphyria, cancers of uterus and genital organs, breast cancers, history of stroke or blood clots. It should not be used in a case of miscarriage and tissue left in the uterus.
Progesterone softgel capsule contains micronised progesterone, which is structurally and biologically identical to natural endogenous progesterone. Micronisation increases the bioavailability of progesterone. When micronised progesterone is administered after meals, maximal serum progesterone levels are significantly increased. Progesterone concentrations in the endometrial and breast tissue attain high level. Progesterone is approximately 96%-99% bound to serum proteins, primarily to serum albumin (50%-54%). Progesterone is metabolized to pregnanediols and pregnanolones in the liver. The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the bile and urine. Progesterone metabolites, which are excreted in bile, may undergo enterohepatic circulation.
Ketoconazole inhibits the metabolism of progesterone.
Progesterone is devoid of estrogenic, androgenic and mineralocorticoid effects. Mild somnolence and other CNS side effects like depression, breast tenderness and bloating are reported. Side effects are less when vaginal route is used.
Severe renal insufficiency, diabetes mellitus, seizures, migraine, headache, heart diseases, depression.