Generic medicine

Ranitidine Hydrochloride

Ranitidine is indicated in: Treatment of active duodenal ulcer Benign gastric ulcer Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent Post operative stress ulcer. Zollinger-Ellison Syndrome. Gastroesophageal reflux disease (GERD). ... Read moreRanitidine is indicated in: Treatment of active duodenal ulcer Benign gastric ulcer Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent Post operative stress ulcer. Zollinger-Ellison Syndrome. Gastroesophageal reflux disease (GERD). Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient. Recurrent haemorrhage in patients with bleeding peptic ulcer. Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients.

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101

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Clinical notes

Applications:
  • Zollinger-Ellison syndrome
Indication Notes:
Ranitidine is indicated in: Treatment of active duodenal ulcer Benign gastric ulcer Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent Post operative stress ulcer. Zollinger-Ellison Syndrome. Gastroesophageal reflux disease (GERD). ... Read moreRanitidine is indicated in: Treatment of active duodenal ulcer Benign gastric ulcer Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent Post operative stress ulcer. Zollinger-Ellison Syndrome. Gastroesophageal reflux disease (GERD). Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient. Recurrent haemorrhage in patients with bleeding peptic ulcer. Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients.
Avoid In:

N/A

Contraindication Notes:
Patients hypersensitive to Ranitidine
Ranitidine competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. It does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Delayed absorption and increased peak serum concentration with propantheline bromide. Ranitidine minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol. May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide). May reduce bioavailability with antacids.
Ranitidine is well tolerated and side effects are usually uncommon. Altered bowel habit, dizziness, rash, tiredness, reversible confusional states, headache, decreased blood counts, muscle or joint pain have rarely been reported.
Ranitidine is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by haemodiaiysis.
Pregnancy: Ranitidine crosses the placenta. But there is no evidence of impaired fertility or harm to the foetus due to Ranitidine. Like other drugs, Ranitidine should only be used during pregnancy if considered essential.Lactation: Ranitidine is excreted in human breast milk. Caution should be exercised when the drug is administered to a nursing mother.
Ranitidine should be given in reduced dosage to patients with impaired renal and hepatic function.
Use in elderly patients: In clinical trial the ulcer healing rates have been found similar in patients age 65 and over with those in younger patients. Additionally, there was no difference in the incidence of adverse effects.

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