Verapamil Hydrochloride

Verapamil Tablet: The dose of Verapamil should be individualized by titration and the drug should be administered with food. For essential hypertension the initial dose should be given 180 mg in the morning. If adequate response is not obtained with 180 mg of Verapamil then the dose may be titrated by following manner: 240 mg each morning. 180 mg each morning plus 180 mg each evening. 240 mg every 12 hourly. For angina the usual dose is 80 mg to 120 mg three times a day. For arrythmias in digitalized patients, Verapamil should be given 240 mg to 360 mg in divided doses, depending on the severity of the condition. Divided doses up to 180 mg/day may occasionally be needed. Verapamil Injection: Adults: 5 mg slowly intravenously, in tachycardias and hypertensive crises, if necessary repeat after 5 to 10 minutes. Drip infusion to maintain the therapeutic effect: 5-10 mg/hour in physiological saline, glucose, laevulose or similar solutions, on average up to a total dose of 100 mg/day. Children: Newborn: 0.75-1 mg (0.3-0.4 ml) Infants: 0.75-2 mg (0.3-0.8 ml) Children age 1-5 years: 2-3 mg (0.8-1.2 ml) Age 6-14 years: 2.5-5 mg (1-2 ml) of Verapamil, given intravenously, depending on age and action. The injection should be made slowly under electrocardiographic control and only until onset of the effect. Intravenous infusion in hypertensive crises: initially 0.05-0.1 mg/kg/hour; if the effect proves to be insufficient, the dose is increased at 30-60 minute intervals until twice the dose or more is reached. Average total dose up to 1.5 mg/kg/day.