Inj. Combipen
Injection · IM · (3lac unit + 1lac unit) / vial · 1 vial
৳17.19
Inj.
Combipen
Procaine Penicillin + Benzyl Penicillin
— ACME Laboratories Ltd.
(3lac unit + 1lac unit) / vial
Presentations
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Cat
20,000–40,000 units/kg q6–8h IM.
Horse
20,000–24,000 units/kg q24h I
Cattle
22,000–66,000 units/kg q24h IM. SQ use is discouraged
Dog
20,000–40,000 units/kg q6–8h IM.
Human
Add 3 ml of water for injection and shake vigorously.Adults: 4,00,000 units once daily or twice daily.Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled.Intramuscular injection is the only route of administration of Procaine Penicillin.
Administration: This should be injected IM into the buttocks, thigh, deltoid or triceps muscle. In case continuous injection is necessitated, the injection site should be changed every time.
Swine
15,000–25,000 units/kg q24h IM.
Clinical notes
Applications:
N/A
Indication Notes:
It is indicated for the treatment or prevention of any infection caused by Penicillin sensitive bacteria where a long acting Penicillin is required. It is indicated in- Gonorrhoea caused by Penicillin sensitive microorganisns Prevention of endocarditis during dental procedures Gas-gangrene following amputation
Avoid In:
N/A
Contraindication Notes:
Hypersensitivity to penicillin.
Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases.Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.
Potentially hazardous interactions: invitro Penicillin inactivates Amino- glycosides, so that they should not be mixed in infusion fluids.
Allergic reactions may occur but usually resolve on cessation of therapy.
Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.
Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.