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Dirovet
Drug Class: Antiprotozoal
Generic Drug: Metronidazole
View Alternative Brand Names (9)Manufacturer: Acme Laboratories LTD.
Basic information
Presentation and price
10 gm sachet
100 gm sachet
Dose and dosage
1 g/2-3 L drinking water daily for 5 days.
40 mg/kg once daily for 5 days or 100 mg/kg on alternate days for 3 treatments or 200
4 g/25 kg body weight daily for 5-7 days
1 g/15 kg body weight daily for 5-7 days.
1 g/15 kg body weight daily for 5-7 days.
4 g/25 kg body weight daily for 5-7 days
4 g/25 kg body weight daily for 5-7 days
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Poultry: Anaerobic bacterial infections, Necrotic enteritis, ulcerative enteritis, gangrenous dermatitis etc Protozoal infection like Histomoniasis, Trichomoniasis etc and ascetic syndrome.
Pigeon: Trichomoniasis (Canker).
Dog & Cat: Anaerobic bacterial infections like meningitis, cholangitis, sepsis etc. giardiasis and other protozoal infection etc.
Metronidazole is an antibacterial and antiprotozoal drug used frequently in small animals, primarily for GI problems. It is a second-generation nitroimidazole in which the activity involves generation of free nitro radicals via metabolism within protozoa and bacteria. Metronidazole disrupts DNA in the organism via reaction with intracellular metabolite. Its action is specific for anaerobic bacteria and protozoa. Resistance is rare. It is active against some protozoa, including Trichomonas spp., Giardia spp., and intestinal protozoal parasites. It also has in vitro activity against anaerobic bacteria and Helicobacter spp.
The most severe adverse effect is caused by toxicity to the CNS. It is highly lipophilic and readily crosses the blood–brain barrier. High doses have caused lethargy, CNS depression, ataxia, tremors, seizures, vomiting, and weakness.
Fetal abnormalities have not been demonstrated in animals with recommended
doses but use cautiously during pregnancy.
Store below 30° C and dry place, protected from light. Keep all medicines out of reach of children.