Tab. Eluxan
Tablet · PO · 100mg / tablet · 1 tablet
৳170
Tab.
Eluxan
Eluxadoline
— Ziska Pharmaceuticals Ltd.
100mg / tablet · 75mg / tablet
Presentations
Tab. Eluxan
Tablet · PO · 75mg / tablet · 1 tablet
৳125
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Human
The recommended dosage in adults is 100 mg twice daily taken with food.The recommended dosage is 75 mg twice daily taken with food in patients who: are unable to tolerate the 100 mg dose. are receiving concomitant OATP1B1 inhibitors. have mild or moderate hepatic impairment. Discontinue Eluxadoline in patients who develop severeconstipation.If a dose is missed, take the next dose at the regular time; do not take 2 doses at once
Clinical notes
Applications:
N/A
Indication Notes:
Eluxadoline is indicated in adults for the treatment of irritable bowel syndrome with diarrhea (IBS-D).
Avoid In:
N/A
Contraindication Notes:
Known or suspected biliary duct obstruction, sphincter of oddi disease or dysfunction & pancreatitis.
Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist & delta opioid receptor antagonist. Eluxadoline works directly in intestine to reduce peristalsis, also makes the nerves in intestine less sensitive to stimulation.
Oral Contraceptive, Cyclosporine, Probenecid, Rosuvastatin.
Most common adverse reactions are constipation, nausea andabdominal pain.
Pregnancy: Not established.Lactation: Not established.
Sphincter of Oddi spasm and Pancreatitis.Patients who should be monitored closely- without a gallbladder with new or worsening abdominal pain with nausea and vomiting with acute biliary pain with liver or pancreatic enzyme elevation
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.Hepatic Impairment: It is contraindicated in patients with severe hepatic impairment.