Eposis

Treatment of anemia in chronic renal failure: Erythropoietin is administered to maintain hemoglobin concentration between 11 to 12 g/dl and hematocrit of 33-36 % in adults.Starting dose: Adult: Usually 50 to 100 lU/kg three times in a week (TIW) by IV or Subcutaneous route. Pediatric: 50 lU/kg TIW by IV or Subcutaneous route. Dose adjustment: Dose should be increased if hematocrit doses not increase by 5 to 6 points after 8 weeks therapy, and hematocrit is below suggested target range. Dose should be reduced when hematocrit approaches 36% or hematocrit increases >4 points in any 2-week period.Maintenance dose: Maintenance dose must be individualized for each patient. In patients undergoing dialysis, the median maintenance dose is 75 lU/kg TIW, with a range from 12.5 to 525 lU/kg TIW as directed by the physician. In CRF patients not on dialysis, maintenance dose is 75 to 150 lU/kg/week.Treatment of Anemia in Cancer Patients on Chemotherapy:Starting dose: Adult: 150 lU/kg TIW by Subcutaneous route or 40,000 IU Subcutaneous route weekly. Pediatric: 25 to 300 lU/kg 3 to 7 times per week by Subcutaneous or IV route. Dose adjustment: If the response is not satisfactory, the dose should be increased to 300 lU/kg TIW. If the hematocrit exceeds 40%, the dose should be withheld until the hematocrit falls to 36%.The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit.Surgery Patients: The recommended dose is 300 lU/kg/day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. An alternate dose schedule is 600 lU/kg subcutaneously in once weekly dose (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.Zidovudine-treated HIV-infected Patients:Starting dose Adult: 100 lU/kg as an IV or Subcutaneous injection TIW for 8 weeks. Pediatric: 50 to 400 lU/kg 2 to 3 times per week by Subcutaneous or IV route. Dose adjustment: If the response is not satisfactory, the dose should be increased by 50-1001U/kg TIW. Response should be evaluated every 4 to 8 weeks thereafter and the dose adjusted accordingly by 50 to 100 lU/kg increments TIW.Maintenance dose: The dose is titrated to maintain the hematocrit between 33-36%. Administration: Do not shake. It is not necessary to shake Erythropoietin. Prolonged vigorous shaking may denature any glycoprotein, rendering it biologically inactive. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Administer as an intravenous injection over 1-2 minutes. In patients on dialysis, the injection should follow the dialysis procedure. Slow injection over 5 minutes may be beneficial to those who experience flu-like symptoms. Do not administer by intravenous infusion or in conjunction with other drug solutions. For the subcutaneous route, a maximum of 1 ml_ at one injection site should generally not be exceeded. In the case of larger volumes, more than one site should be chosen for the injection.