Fentizol VT - Fenticonazole Nitrate [Vaginal Tablet] | VetSafeCare.Com

Brand

Fentizol VT

Fenticonazole Nitrate [Vaginal Tablet] — Square Pharmaceuticals Ltd.
600mg / vaginal tablet

Alternatives

2

Routes

VAG

Presentations

1

Generic profile Browse alternatives View combinations

Presentations

Vaginal Tablet · 600mg / vaginal tablet

1 vaginal tablet

৳120

Dose rules

No structured dose rules are linked to this brand yet.

Dose reference

Human

Trichomonas or mixed (Trichomonas and Candida albicans) vaginal infections: One 600 mg VT (followed by a second administration 24 hours later, if necessary). Candida albicans infections: One single 600 mg VT administration in the evening. Should the symptoms persist, a second administration may be repeated after three days. The tablet must be introduced deep into the vagina and pushed well up to the fornix. To avoid re-infection, it is recommended that the partner undergoes concurrent treatment with Fenticonazole Cream or similar Azole Cream.

Clinical notes

Applications:
  • Vulvovaginal candidiasis
Indication Notes:
Fenticonazole Nitrate vaginal tablet is indicated for: Genital candidiasis (vulvovaginitis, colpitis, infectious fluor) Trichomonasis Vaginal infections sustained by mixed forms of Trichomonas vaginalis and Candida albicans.
Avoid In:

N/A

Contraindication Notes:
Contraindicated in case of hypersensitivity to Fenticonazole and other Imidazoles.
Fenticonazole is a potent broad-spectrum antimycotic agent. It exerts fungistatic and fungicidal actions on dermatophytes, pathogenic yeasts, dimorphous fungi and molds. In addition, Fenticonazole is active against gram-positive bacteria and is therefore indicated in mycoses associated with bacterial super infections. Fenticonazole is also active, both in vitro and in vivo, against Trichomonas vaginalis. Fenticonazole exerts its unique antimycotic action through following three ways: Inhibiting the biosynthesis of ergosterol leading to the damage of fungal cell membrane. Causing certain changes in oxidative and peroxidative enzyme activities inside fungal cell. This leads to an intracellular build-up of toxic concentrations of hydrogen peroxide resulting in cell necrosis. Inhibiting the secretion of aspartic proteases (responsible for pathogenicity) by Candida albicans. The amount of Fenticonazole absorbed by the transcutaneous route is negligible.
After intravaginal administration slight transient burning (which usually disappears rapidly) may occasionally happen. Prolonged topical application may cause sensitisation reactions. Fenticonazole is generally well tolerated by the mucous membranes; only exceptionally mild and transient erythematous reactions have been reported. After topical application or intravaginal administration, a slight burning sensation may occur, usually subsiding soon. Should more persistent irritation occur or resistant micro-organism develop, suspend the treatment and seek the doctor's advice. Due to poor absorption of Fenticonazole, no systemic effects should occur, provided the above instructions are carefully observed.
As systemic absorption is very low, the possibility of overdose is rare. In case of accidental swallowing, emesis or gastric lavage should be done. After vomiting, active charcoal along with water/lemon juice and laxative should be given to the patient.
It is not recommended in pregnancy. Safety in breastfeeding has not been established.
Fenticonazole Nitrate is not recommended for children.