Soln. Fludin
Ophthalmic Solution · Ophthalmic · 1% · 5 ml
৳950
Soln.
Fludin
Trifluridine
— Aristopharma Ltd.
1%
· 5 ml
Presentation
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Human
Children above 6 years of age & adults: Instill 1 drop every 2 hrs while awake; maximum 9 drops/day until the corneal ulcer has completely re-epithelialized. After re-epithelialization: Instill 1 drop every 4 hrs or at least 5 drops/day for 7 days is recommended. If there are no signs of improvement after 7 days of therapy or complete re-epithelialization has not occurred after 14 days of therapy, other forms of therapy should be considered. Continuous administration of Trifluridine eye drops for periods exceeding 21 days should be avoided because of potential ocular toxicity.
Clinical notes
Applications:
- Keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex viruses
Indication Notes:
Trifluridine Sterile Eye Drops is indicated for the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus, type 1 and 2.
Avoid In:
N/A
Contraindication Notes:
Contraindicated in patients who develop hypersensitivity reactions or chemical intolerance to Trifluridine.
Trifluridine is a fluorinated pyrimidine nucleoside analog which interferes with DNA synthesis of herpes simplex virus, type 1 and 2 and vaccinia virus. It stops replication of herpes viral DNA in 3 ways: Competitive inhibition of viral DNA polymerase, Incorporation into and termination of the growing viral DNA chain and Inactivation of the viral DNA polymerase.
Reported side effects are mild, transient burning or stinging sensation upon instillation. Other side effects are superficial punctate keratopathy, epithelial keratopathy, hypersensitivity reaction, stromal edema, irritation, keratitis sicca, hyperemia and increased intraocular pressure.
Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Trifluridine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Use in lactation: It is unlikely that Trifluridine is excreted in human milk after instillation of Trifluridine eye drops because of the relatively small dosage. The drug should not be prescribed for nursing mothers unless the potential benefits outweigh the potential risks.
Trifluridine should be prescribed only for patients who have a clinical diagnosis of herpetic keratitis.
Use in children: Safety and effectiveness in pediatric patients below 6 years of age have not been established. Use in elderly patients: No overall clinical differences in safety or effectiveness have been observed between elderly and other adult patients.