Soln. Laxitol
Oral Solution · Oral · 10gm / 15ml · 50 ml
৳65
Soln.
Laxitol
Lactitol Monohydrate
— Eskayef Pharmaceuticals Ltd.
10gm / 15ml
· 50 ml
Presentation
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Human
Lactitol can be mixed with hot or cold beverages, puddings etc. Dosage will require adjustment to obtaine one daily bowel movement in constipated patients and two daily bowel movements in patients with portal systemic encephalopathy. In constipation: In adult: The initial daily dosage should be 20 g taken in a single dose with the morning or evening meal. After a few days, a daily dose of 10 g may be sufficient. Children: The mean dosage is 0.25 g/kg body weight daily. 1 to 6 years: 2.5 to 5 gm 6 to 12 years: 5 to 10 gm 12 to 16 years: 10 to 20 gm The effect of lactitol has been found mostly to occur within a few hours after intake. But in some cases the first laxative response may be delayed until the second or third day of administration. Therefore patients should be advised to maintain an adequate daily fluid intake. In portal systemic encephalopathy: The dose should be adjusted according to the severity of the patient’s disease and their individual response. The initial recommended dose is 0.5 to 0.7 gm/kg body weight daily, divided into three daily doses with meals.
Clinical notes
Applications:
N/A
Indication Notes:
Lactitol Monohydrate is indicated in chronic idiopathic constipation (CIC), acute and chronic portal systemic encephalopathy.
Avoid In:
N/A
Contraindication Notes:
Patients with known hypersensitivity to any of the ingredients of this preparation.
Lactitol Monohydrate is a disaccharide derivatives consisting of galactose and sorbitol, which is only minimally absorbed and is not hydrolysed by the disaccharidases of the GIT and thus reaches the colon unchanged. In the colon it is broken down to short chain low molecular weight organic acids by the intestinal flora, resulting in an increase in osmotic pressure in the colon, thereby causing an increase in the stool water content and stool volume, which explains the laxative effect. Lactitol Monohydrate produces its effect in the lumen of the colon, where it is virtually 100% bioavailable. It is absorbed only in minimal amounts. Up to 2% can be found unchanged in the urine.
Antacids and neomycin should not be given simultaneously with Lactitol to cirrhotic patients with portal systemic encephalopathy. Lactitol may increase potassium loss caused by other drugs e.g. thiazide diuretics, corticosteroids, carbenoxolone, amphotericin B and it may enhance the risk of toxic effects of glycosides in patients receiving concomitant therapy.
At the start of the treatment with lactitol may produce abdominal discomforts such as flatulence, pain, cramps or sensation of fullness. Such effects tend to diminish or disappear after a few days of regular intake of Lactitol. Occasionally, nausea or anal pruritus has been reported in some cases.
Lactitol is minimally absorbed systemically following oral administration, and it is unknown whether maternal use will result in fetal exposure to the drug. There are no data on the presence of lactitol in human or animal milk, the effects on the breastfed infant, or the effects on milk production.
Elderly or debilitated patients receiving long-term treatment with lactitol should have their serum electrolytes monitored regularly. As for all laxatives, pre-existing fluid or electrolyte imbalance should be corrected before starting treatment with lactitol. Following treatment of Lactitol, hydrogen may accumulate in the bowel. Patients who need to undergo electrocauterisation procedure should therefore have a thorough bowel cleansing with a non-fermentable solution. Lactitol is not recommended in case s of ileostomy or colostomy. Prolonged use of laxatives without interruption should be avoided.
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