Soln. Nispore
Ophthalmic Solution · Ophthalmic · 0.3% · 5 ml
৳80
Soln.
Nispore
Fluconazole (Ophthalmic)
— Incepta Pharmaceuticals Ltd.
0.3%
· 5 ml
Presentation
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Human
Instill 1 drop to be instilled into the affected eye(s) 5 times daily.
Clinical notes
Applications:
- Fungal corneal ulcers
Indication Notes:
For the treatment of fungal corneal ulcers/ keratitis.
Avoid In:
N/A
Contraindication Notes:
The drug is contraindicated in patients with hypersensitivity to azoles.
Fluconazole is fungistatic in action. It inhibits cytochrome P-450 14-α demethylase in susceptible fungi which leads to accumulation of lanosterol and decreased concentration of ergosterol thereby altering cellular membrane resulting in increased membrane permeability, leakage of essential elements and impaired uptake of precursor molecules to DNA.
Fluconazole can alter pharmacokinetics of certain drugs undergoing hepatic metabolism.
This drug is generally well tolerated. Eosinophillia has been reported in some patients.
Use in pregnancy: Pregnancy category C. There are no adequate and well-controlled studies in pregnant women. Fluconazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Use in lactation: Nursing mother should not be given as the drug is excreted in breast milk in concentration similar to plasma.
Use of fluconazole may result in overgrowth of non-susceptible strains of candida other than Candida albicans