Omastin - Fluconazole | VetSafeCare.Com

Cap.

Omastin

Fluconazole — Beximco Pharmaceuticals Ltd.
200mg / capsule · 150mg / capsule · 50mg / capsule · 200mg / 100 ml · 50mg / 5 ml

Alternatives

90

Routes

PO, IV

Presentations

5

Generic profile Browse alternatives View combinations

Presentations

Capsule · 200mg / capsule

1 capsule

৳25

Capsule · 150mg / capsule

1 capsule

৳22

Capsule · 50mg / capsule

1 capsule

৳8

IV Infusion · 200mg / 100 ml

100 ml

৳200

Powder for Suspension · 50mg / 5 ml

35 ml

৳78

Dose rules

No structured dose rules are linked to this brand yet.

Dose reference

Human

Adult (oral)- Vaginal candidiasis: 150 mg as a single dose. Oropharyngeal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of this infection generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse. Esophageal candidiasis: 200 mg on the first day, followed by 100 mg once daily. Doses up to 400 mg/day may be used. Patients should be treated for a minimum of three weeks and for at least two weeks following resolution of symptoms. Systemic candida infections: Optimal therapeutic dosage and duration of therapy have not been established. Sometimes, doses of up to 400 mg daily have been used. Urinary tract infections caused by candida and peritonitis: 50-200 mg daily have been used. Cryptococcal meningitis: 400 mg on the first day, followed by 200 mg once daily. Prophylaxis in patients undergoing bone marrow transplantation: 400 mg once daily. Child (oral): Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg is recommended. Intravenous- Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then 200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis) Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of cryptococcal meningitis, by IV, 100-200 mg daily.

Clinical notes

Applications:
  • Vaginal candidiasis or thrush
Indication Notes:
Fluconazole is indicated for the treatment of vaginal candidiasis, oropharyngeal & esophageal candidiasis and cryptococcal meningitis. It is also effective for the treatment of urinary tract infection caused by candida, peritonitis and systemic candida infections (including candidemia, disseminated candidiasis and pneumonia).
Avoid In:

N/A

Contraindication Notes:
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential component of fungal cell membrane which is responsible for the synthesis of ergosterol.
Concomitant use of cyclosporin or phenytoin with Fluconazole increases the plasma level of cyclosporin or phenytoin. Concomitant use of Fluconazole & warfarin prolongs the prothrombin time. Rifampicin level is decreased when used with Fluconazole.
Fluconazole is well tolerated. Most common side effects of using Fluconazole includes nausea, vomiting, abdominal pain, diarrhoea, headache and skin rash.
US FDA Pregnancy category of Fluconazole is C. So, Fluconazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Fluconazole should be administered with caution to patients having proarrhythmic conditions.