Orthogen

• Osteoarthritis (degenerative arthritis)

This preparation is indicated in- Osteoarthritis & rheumatoid arthritis Difficulties in flexibility & mobility Joint pain & inflammation Joint discomfort & stiffness (knee extension) Impaired joint function

N/A

Contraindicated in patients with known hypersensitivity to chicken, egg & shellfish.

Undenatured Type II collagen (UC-II): Undenatured Type II collagen (UC-II) is a nutritional supplement derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. UC-II has unique mechanism of action. UC-II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of UC-II interact with Peyer’s patches (lymphoid tissue) of small intestine and it transforms T-cells into T- regulatory cells. T-regulatory cells then migrate to joint area and secrete anti-inflammatory mediators (cytokines), including the transforming growth factor-beta (TGF beta) and interleukin 10 (IL-10). Thus it reduces joint inflammation and promotes cartilage repair. According to ORSI (osteoarthritis research society international), oral administration of UC-II diminished deterioration of articular cartilage of osteoarthritis (OA).Glucosamine sulfate: Glucosamine sulfate is a natural supplement. It is a sugar protein that helps build cartilage. Glucosamine, a normal constituent of glycosaminoglycans in cartilage matrix and synovial fluid, could have various pharmacological actions in articular cartilage and joint tissues. In randomized, placebo-controlled clinical trial, long-term administration of glucosamine sulfate can prevent joint structure changes in patients with osteoarthritis of the knee with a significant improvement in symptoms.Boswellia serrata: This plant extract promotes joint health by inhibiting inflammatory factors such as the 5-lipoxygenase (5-LOX) enzyme and leukotriene B4, which affect aging joints. Extract of Boswellia serrata has been clinically studied for osteoarthritis, joint function & joint pain. Boswellia may also help reduce cartilage damage in arthritis. In a placebo-controlled clinical study, Boswellia extract improves signs of joint discomfort in just 8 weeks. Boswellia serrata as a promising alternative to NSAIDs.Boron (calcium fructoborate): It is a patented complex of calcium, fructose & boron found naturally in fresh and dried fruits, vegetables and herbs. Calcium fructoborate significantly reduces the C-reactive protein in humans. This unique plant-mineral complex is contribute to bone health by controlling the inflammation associated with loss of bone mineral density.

There have been no reports of significant drug Interactions of UC-II, Boswellia serrata, Glucosamine sulfate, Calcium fructoborate. But in case of Glucosamine sulfate & Boswellia serrata there are a chance of drug interaction with blood thinner medications (e,g warfarin & heparin).

The combination of Undenatured Type II collagen, Glucosamine, Boswellia & Boron is generally well-tolerated in the recommended dose. Overdose may cause headache & constipation.

The signs and symptoms of overdose include nausea, vomiting, diarrhoea, constipation and abdominal discomfort.

Not recommended duration pregnancy and lactation.

No special studies were confirmed in patients with renal and/or hepatic insufficiency. However, administration to these patients with severe renal or hepatic insufficiency should be under appropriate medical supervision.