Phendrin - Diphenhydramine Hydrochloride | VetSafeCare.Com

Syrp.

Phendrin

Diphenhydramine Hydrochloride — Salton Pharmaceuticals Ltd.
10mg / 5 ml

Alternatives

14

Routes

PO

Presentations

1

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Presentations

Syrup · 10mg / 5 ml

100 ml

৳22.08

Dose rules

No structured dose rules are linked to this brand yet.

Dose reference

Cat

As an antihistamine:
a) 0.5 mg/kg PO q12h; liquid formulation is distasteful (Messinger 2000)
b) 2–4 mg (total dose) q12–24h (Hnilica 2003)
c) 2–4 mg/kg PO q8h (Scherk 2006)
d) For severe urticaria and angioedema: 2 mg/kg IM twice daily as needed (with steroids: prednisone 2 mg/kg IM twice daily and epinephrine 1:10,000 (0.5–2 mL SC) (Giger & Werner 1989)
For adjunctive treatment of pancreatitis:
a) 2–4 mg/kg PO q8h (Scherk 2005)

Horse

As an antihistamine:
a) For adjunctive therapy of anaphylaxis: 0.25–1 mg/kg IV or IM (Evans 1996)
b) For allergic skin diseases (atopy): 1–2 mg/kg twice daily (route not specified) (Miller 2005)
c) For allergic skin diseases (atopy): 0.75–1 mg/kg PO q12h (Rees 2004)
d) For adjunctive tx of pruritus: 1–2 mg/kg PO two to three times a day. (Marsella 2008)

Cattle

a) For adjunctive therapy of anaphylaxis: 0.5–1 mg/kg IM or IV (used with epinephrine and steroids) (Clark 1986)
b) For adjunctive therapy of aseptic laminitis: During the acute phase (with corticosteroids): 55–110 mg/100 kg body weight (0.55–1.1 mg/kg) IV or IM (Berg 1986)

Dog

As an antihistamine:
a) 2–4 mg/kg q8–12h PO; 1 mg/kg q8–12h IM, SC, IV (do not exceed 40 mg total dose) (Papich 2000)
b) 2.2 mg/kg PO twice daily–three times daily (Peikes 2003)
c) For severe urticaria and angioedema: 2 mg/kg IM twice daily as needed (with steroids: prednisone 2 mg/kg IM twice daily and epinephrine 1:10,000: 0.5–2 mL SC) (Giger & Werner 1989)(
d) For canine atopic dermatitis: 25–50 mg (total dose) PO three times daily. (Hill 2007)
e) For treatment of anaphylaxis (associated with doxorubicin chemotherapy): 3–4 mg/kg IM with dexamethasone sodium phosphate (0.5–1 mg/kg IV) wait for reaction to subside before restarting infusion at slower rate. (Vail 2006)
f) For preoperative therapy for splenic mast cell tumors: 2 mg/kg PO three times daily with famotidine (0.5 mg/kg PO once daily) are used to prevent anaphylaxis. (Garrett 2006)
g) For adjunctive tx of pruritus: 2–4 mg/kg PO two to three times a day. (Marsella 2008)

Prevention of motion sickness/antiemetic:
a) 2–4 mg/kg PO, IM q8h (Washabau & Elie 1995), (Richter 2009) For preoperative therapy for splenic mast cell tumors:
a) 2 mg/kg PO three times daily with famotidine (0.5 mg/kg PO once daily) are used to prevent anaphylaxis. (Garrett 2006)
For treatment of the reverse sneeze syndrome:
a) 25 mg PO three to four times a day, dosage is usually decreased to once or twice a week for maintenance (Prueter 1989)

Human

Adult- Most allergic conditions: 25-50 mg three times a day with a further 50 mg at night. Children- 1 to 5 years of age: 5 mg i.e., 2.5 ml of elixir 4 times a day More than 6 years of age: 10 mg i.e. 5 ml of elixir 4 times a day

Ferrets

a) Prevaccination: 2 mg/kg PO, IM or IV 10 minutes prior to vaccination (Williams 2000)
b) Pretreatment before doxorubicin: 5 mg (total dose) IM (Johnson 2006)

Rabbit

1–2 mg/kg PO twice daily as an antihistamine (Morrisey & Antinoff 2003), (Antinoff 2008)

Birds (Other)

For adjunctive treatment of pruritus causing feather picking in Psittacines:
a) 2 mg/kg PO q12h (Siebert 2003)

Guinea pigs

7.5 mg/kg PO (Adamcak & Otten 2000)

Clinical notes

Applications:

N/A

Indication Notes:
Diphenhydramine is indicated for the treatment of followings: Seasonal, perennial, vasomotor rhinitis Urticaria, angioneurotic oedema, anaphylaxis Pruiritic conditions Premedication for emesis and motion sickness Miscellaneous like meniere's disease and parkinsonism
Avoid In:

N/A

Contraindication Notes:
Known hypersensitivity to Diphenhydramine Hydrochloride, Ammonium chloride is contra-indicated in presence of impaired hepatic or renal function.
Diphenhydramine is an antihistamine with anticholinergic and sedative effects. It competes with histamine for H1-receptor sites on effector cells in the GI tract, blood vessels and respiratory tract.
Diphenhydramine administration significantly reduces the absorption of the antituberculous agent para-aminosalicyclic acid (PAS) from the gastrointestinal tract. CNS depressants may potentiate the sedative action of Diphenhydramine. Anticholinergic drugs may potentiate Diphenhydramine’s anticholinergic side effects.
Side effect includes sedation, dizziness, tinnitus, fatigue, ataxia, blurred vision, diplopia, euphoria, and epigastric discomfort.
Symptoms: Impaired consciousness; psychosis, seizures, antimuscarinic symptoms (e.g. mydriasis, tachycardia, tachyarrhythmias), resp failure, rhabdomyolysis; acute delirium with visual and auditory hallucination (topical). Management: Supportive and symptomatic treatment. Convulsions and marked CNS stimulation may be treated with IV diazepam.
Category B: There are no adequate and well controlled studies in pregnant women using diphenhydramine hydrochloride. Therefore, diphenhydramine hydrochloride should be used in pregnancy only if clearly needed. Diphenhydramine hydrochloride has been reported to be excreted in breast milk and thus, use of diphenhydramine hydrochloride in lactating mother is not recommended.
Caution should be exercised with patients in whom drowsiness is undesirable e.g., drivers, machine operators. Concomitant consumption of alcohol or central nervous system (CNS) depressants will potentiate drowsiness.